Acid, weakly acidic and non-acid gastro-oesophageal reflux: differences, prevalence and clinical relevance

被引：47

作者：

Sifrim, D ^{[1
]}

机构：

[1] Catholic Univ Louvain, Ctr Gastroenterol Res, B-3000 Louvain, Belgium

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2004年 / 16卷 / 09期

关键词：

gastro-oesophageal reflux; pH-metry; impedance;

D O I：

10.1097/00042737-200409000-00002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

patients with gastro-oesophageal reflux disease (GORD), oesophageal symptoms and mucosal damage traditionally are related to acid-reflux episodes with pH lower than 4. Oesophageal or extra-oesophageal symptoms of GORD may also be associated with less acidic reflux (pH 4-7). New methodologies have evolved to complement pH monitoring for characterisation of less acidic gastro-oesophageal reflux. This review will focus on definition, detection, pathophysiology and symptom association of weakly acidic and non-acid reflux, in both adult and paediatric populations.

引用

页码：823 / 830

页数：8

共 65 条

[1]

[Anonymous], 1991, J GASTROINTEST MOTIL, V3, P151, DOI DOI 10.1111/J.1365-2982.1991.TB00061.X

[2] LONG-TERM AMBULATORY ENTEROGASTRIC REFLUX MONITORING - VALIDATION OF A NEW FIBEROPTIC TECHNIQUE [J].

BECHI, P ;

PUCCIANI, F ;

BALDINI, F ;

COSI, F ;

FALCIAI, R ;

MAZZANTI, R ;

CASTAGNOLI, A ;

PASSERI, A ;

BOSCHERINI, S .

DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (07) :1297-1306

[3]

Blondeau K, 2004, GASTROENTEROLOGY, V126, pA99

[4] ANALYSIS OF 24-HOUR ESOPHAGEAL PRESSURE AND PH DATA IN UNSELECTED PATIENTS WITH NONCARDIAC CHEST PAIN [J].

BREUMELHOF, R ;

NADORP, JHSM ;

AKKERMANS, LMA ;

SMOUT, AJPM .

GASTROENTEROLOGY, 1990, 99 (05) :1257-1264

[5] DUODENOGASTROESOPHAGEAL REFLUX - RELATIONSHIP TO PH AND IMPORTANCE IN BARRETTS-ESOPHAGUS [J].

CHAMPION, G ;

RICHTER, JE ;

VAEZI, MF ;

SINGH, S ;

ALEXANDER, R .

GASTROENTEROLOGY, 1994, 107 (03) :747-754

[6] Intra-oesophageal distribution and perception of acid reflux in patients with non-erosive gastro-oesophageal reflux disease [J].

Cicala, M ;

Emerenziani, S ;

Caviglia, R ;

Guarino, MPL ;

Vavassori, P ;

Ribolsi, M ;

Carotti, S ;

Pettiti, T ;

Pallone, F .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2003, 18 (06) :605-613

[7] Relationship between acid reflux episodes and gastroesophageal reflux symptoms is very inconstant [J].

Colas-Atger, E ;

Bonaz, B ;

Papillon, E ;

Gueddah, N ;

Rolachon, A ;

Bost, R ;

Fournet, J .

DIGESTIVE DISEASES AND SCIENCES, 2002, 47 (03) :645-651

[8] MECHANISMS OF LOWER ESOPHAGEAL SPHINCTER INCOMPETENCE IN PATIENTS WITH SYMPTOMATIC GASTROESOPHAGEAL REFLUX [J].

DENT, J ;

HOLLOWAY, RH ;

TOOULI, J ;

DODDS, WJ .

GUT, 1988, 29 (08) :1020-1028

[9] Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal [J].

Fletcher, J ;

Wirz, A ;

Young, J ;

Vallance, R ;

McColl, KEL .

GASTROENTEROLOGY, 2001, 121 (04) :775-783

[10] Endoscopy-negative reflux disease. [J].

Galmiche J.P. ;

des Varannes S.B. .

Current Gastroenterology Reports, 2001, 3 (3) :206-214

← 1 2 3 4 5 6 7 →