Indoleamine 2,3-Dioxygenase in Intestinal Immunity and Inflammation

被引：51

作者：

Cherayil, Bobby J. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Pediat Gastroenterol Unit, Charlestown, MA 02129 USA

来源：

INFLAMMATORY BOWEL DISEASES | 2009年 / 15卷 / 09期

关键词：

inflammation in IBD; mucosal immunology; ARYL-HYDROCARBON RECEPTOR; REGULATORY T-CELLS; DENDRITIC CELLS; TRYPTOPHAN CATABOLISM; EXPRESSION; INHIBITION; DIFFERENTIATION; GAMMA; IGA; PROLIFERATION;

D O I：

10.1002/ibd.20910

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catabolizing enzyme that has a number Of immunoregulatory effects. It is expressed at high levels in the gastrointestinal tract, p,particularly ill the small intestine, and has been implicated in the control of intestinal inflammation. However, its, precise role in intestinal immunity is not well Understood. This review will summarize the current state of knowledge about IDO function, particularly as it pertains to inflammatory responses in the gut.

引用

页码：1391 / 1396

页数：6

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