Indoleamine 2,3-Dioxygenase in Intestinal Immunity and Inflammation

被引：51

作者：

Cherayil, Bobby J. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Pediat Gastroenterol Unit, Charlestown, MA 02129 USA

来源：

INFLAMMATORY BOWEL DISEASES | 2009年 / 15卷 / 09期

关键词：

inflammation in IBD; mucosal immunology; ARYL-HYDROCARBON RECEPTOR; REGULATORY T-CELLS; DENDRITIC CELLS; TRYPTOPHAN CATABOLISM; EXPRESSION; INHIBITION; DIFFERENTIATION; GAMMA; IGA; PROLIFERATION;

D O I：

10.1002/ibd.20910

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catabolizing enzyme that has a number Of immunoregulatory effects. It is expressed at high levels in the gastrointestinal tract, p,particularly ill the small intestine, and has been implicated in the control of intestinal inflammation. However, its, precise role in intestinal immunity is not well Understood. This review will summarize the current state of knowledge about IDO function, particularly as it pertains to inflammatory responses in the gut.

引用

页码：1391 / 1396

页数：6

共 60 条

[1] Interferon-γ-modified dendritic cells suppress B cell function and ameliorate the development of experimental autoimmune myasthenia gravis [J].

Adikari, SB ;

Lian, H ;

Link, H ;

Huang, YM ;

Xiao, BG .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 138 (02) :230-236

[2] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[3] Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice [J].

Ball, Helen J. ;

Sanchez-Perez, Angeles ;

Weiser, Silvia ;

Austin, Christopher J. D. ;

Astelbauer, Florian ;

Miu, Jenny ;

McQuillan, James A. ;

Stocker, Roland ;

Jermiin, Lars S. ;

Hunt, Nicholas H. .

GENE, 2007, 396 (01) :203-213

[4]

Barceló-Batllori S, 2002, PROTEOMICS, V2, P551, DOI 10.1002/1615-9861(200205)2:5<551::AID-PROT551>3.0.CO

[5]

2-O

[6] Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].

Bettelli, E ;

Carrier, YJ ;

Gao, WD ;

Korn, T ;

Strom, TB ;

Oukka, M ;

Weiner, HL ;

Kuchroo, VK .

NATURE, 2006, 441 (7090) :235-238

[7] T cell control of the gut IgA response against commensal bacteria [J].

Bos, NA ;

Jiang, HQ ;

Cebra, JJ .

GUT, 2001, 48 (06) :762-764

[8] A crucial role for tryptophan catabolism at the host/Candida albicans interface [J].

Bozza, S ;

Fallarino, F ;

Pitzurra, L ;

Zelante, T ;

Montagnoli, C ;

Bellocchio, S ;

Mosci, P ;

Vacca, C ;

Puccetti, P ;

Romani, L .

JOURNAL OF IMMUNOLOGY, 2005, 174 (05) :2910-2918

[9]

Casola S, 2006, CURR TOP MICROBIOL, V308, P155

[10] The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation [J].

Chen, Wei ;

Liang, Xueqing ;

Peterson, Amanda J. ;

Munn, David H. ;

Blazar, Bruce R. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (08) :5396-5404

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