Highly antiproliferative neutral Ru(II)-arene phosphine complexes

被引：9
|
作者：
Chotard, Florian [1 ]
Dondaine, Lucile [1 ,2 ,3 ]
Balan, Cedric [1 ]
Bettaieb, Ali [2 ,3 ]
Paul, Catherine [2 ,3 ]
Le Gendre, Pierre [1 ]
Bodio, Ewen [1 ]
机构：
[1] Univ Bourgogne Franche Comte, CNRS, UMR6302, ICMUB, F-21000 Dijon, France
[2] PSL Res Univ, EPHE, Lab Immunol & Immunotherapie Canc, F-75000 Paris, France
[3] Univ Bourgogne Franche Comte, LIIC, EA7269, F-21000 Dijon, France
来源：
NEW JOURNAL OF CHEMISTRY | 2018年 / 42卷 / 10期
关键词：
RUTHENIUM COMPLEXES; ANTICANCER AGENTS; ORGANOMETALLIC COMPOUNDS; BIOLOGICAL-PROPERTIES; TITANIUM COMPLEXES; ANTITUMOR-ACTIVITY; METAL-COMPLEXES; IN-VITRO; GOLD; CANCER;
D O I：
10.1039/c7nj04442a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Six ruthenium(II)- and four gold(I)-phosphine based complexes were synthesized and fully characterized. Some of them displayed strong antiproliferative properties for several types of cancer including colon, breast, and lung. Notably, two of the Ru(II) complexes displayed an IC50 of around 2 mM, which is exceptional for these types of complexes. The dramatic impact of the nature of the arene coordinated on the ruthenium center was clearly evidenced.
引用
收藏
页码：8105 / 8112
页数：8
相关论文
共 50 条
  • [1] THIOPHENE BINDING TO NEUTRAL AND CATIONIC RU(II) PHOSPHINE COMPLEXES
    POLAM, JR
    PORTER, LC
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 203 : 454 - INOR
  • [2] Catalytic racemization of secondary alcohols with new (arene)Ru(II)-NHC and (arene)Ru(II)-NHC-tertiary phosphine complexes
    Marozsan, Natalia
    Horvath, Henrietta
    Kovats, Eva
    Udvardy, Antal
    Erdei, Aniko
    Purgel, Mihaly
    Joo, Ferenc
    MOLECULAR CATALYSIS, 2018, 445 : 248 - 256
  • [3] Highly antiproliferative ruthenium(II) and osmium(II) arene complexes with paullone-derived ligands
    Schmid, Wolfgang F.
    John, Roland O.
    Arion, Vladimir B.
    Jakupec, Michael A.
    Keppler, Bernhard K.
    ORGANOMETALLICS, 2007, 26 (26) : 6643 - 6652
  • [4] Assessment of antiproliferative activity of new half-sandwich arene Ru (II) furylbenzhydrazone complexes
    Prabaharan, Ramya
    Rengan, Ramesh
    Umapathy, Devan
    Arockiam, Antony Joseph Velanganni
    Malecki, Jan Grzegorz
    APPLIED ORGANOMETALLIC CHEMISTRY, 2022, 36 (02)
  • [5] Contemporary progresses on neutral, highly emissive Os(II) and Ru(II) complexes
    Chi, Yun
    Chou, Pi-Tai
    CHEMICAL SOCIETY REVIEWS, 2007, 36 (09) : 1421 - 1431
  • [6] Investigation into antiproliferative activity and apoptosis mechanism of new arene Ru(II) carbazole-based hydrazone complexes
    Kamatchi, Thangavel Sathiya
    Subarkhan, Mohamed Kasim Mohamed
    Ramesh, Rengan
    Wang, Hangxiang
    Malecki, Jan Grzegorz
    DALTON TRANSACTIONS, 2020, 49 (32) : 11385 - 11395
  • [7] Analysis of antiproliferative activity of new half-sandwich arene Ru(II) thiophene based aroylhydrazone complexes
    Prabaharan, Ramya
    Arunachalam, Abirami
    Rengan, Ramesh
    DALTON TRANSACTIONS, 2024, 53 (32) : 13469 - 13477
  • [8] Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites
    Pagliaricci, Noemi
    Pettinari, Riccardo
    Marchetti, Fabio
    Tombesi, Alessia
    Pagliaricci, Sara
    Cuccioloni, Massimiliano
    Galindo, Agustin
    Fadaei-Tirani, Farzaneh
    Hadiji, Mouna
    Dyson, Paul J.
    INORGANIC CHEMISTRY, 2024, 63 (17) : 7955 - 7965
  • [9] A weak η1 π-bonding mode for Ru-arene complexes.: Nitrile, isonitrile and phosphine derivatives of Ru-phosphino-arene chelating complexes
    Geldbach, TJ
    Drago, D
    Pregosin, PS
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2002, 643 : 214 - 222
  • [10] Antiproliferative activity of Pt(II) and Pd(II) phosphine complexes with thymine and thymidine
    Messere, Anna
    Fabbri, Enrica
    Borgatti, Monica
    Gambari, Roberto
    Di Blasio, Benedetto
    Pedone, Carlo
    Romanelli, Alessandra
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2007, 101 (02) : 254 - 260
12345