Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

被引：1015
|
作者：
Nasongkla, Norased
Bey, Erik
Ren, Jimin
Ai, Hua
Khemtong, Chalermchai
Guthi, Jagadeesh Setti
Chin, Shook-Fong
Sherry, A. Dean
Boothman, David A.
Gao, Jinming
机构：
[1] Univ Texas, SW Med Ctr, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Adv Imaging Res Ctr, Dallas, TX 75390 USA
来源：
NANO LETTERS | 2006年 / 6卷 / 11期
关键词：
D O I：
10.1021/nl061412u
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide ( SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.
引用
收藏
页码：2427 / 2430
页数：4
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