Quantification in positron emission tomography for research in pharmacology and drug development

被引：25

作者：

Cunningham, VJ ^{[1
]}

Gunn, RN ^{[1
]}

Matthews, JC ^{[1
]}

机构：

[1] Addenbrookes Hosp, ACCI, GlasoSmithKline, Translat Med & Technol, Cambridge, England

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 2004年 / 25卷 / 07期

关键词：

positron emission tomography; quantification; blood flow; metabolic rate for glucose; neuroreceptor function;

D O I：

10.1097/01.mnm.0000134330.38536.bc

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Positron emission tomography (PET) is a quantitative in vivo tracer technique, enabling images of the distribution of biochemical, physiological and pharmacological functions in living tissue, at a resolution of a few millimetres. Applications include the imaging of blood flow rate, metabolic rate and neuroreceptor distribution and function. These applications are playing an increasing role in drug development. This brief article seeks to emphasize how these applications of PET need to rest on a solid quantitative foundation. (C) 2004 Lippincott Williams Wilkins.

引用

页码：643 / 646

页数：4

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