Multiple sclerosis genetics

被引：273

作者：

Sawcer, Stephen ^{[1
]}

Franklin, Robin J. M. ^{[2
,3
]}

Ban, Maria ^{[1
]}

机构：

[1] Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 0QQ, England

[2] Univ Cambridge, Wellcome Trust Med Res Council Cambridge Stem Cel, Cambridge CB2 0QQ, England

[3] Univ Cambridge, Dept Vet Med, Cambridge CB2 0QQ, England

来源：

LANCET NEUROLOGY | 2014年 / 13卷 / 07期

关键词：

GENOME-WIDE ASSOCIATION; CLASSICAL HLA ALLELES; SUSCEPTIBILITY LOCI; COMPLEX GENETICS; RECURRENCE RISKS; MHC HAPLOTYPES; CYP27B1; GENE; NO EVIDENCE; DISEASE; VARIANTS;

D O I：

10.1016/S1474-4422(14)70041-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genome-wide association studies have revolutionised the genetic analysis of multiple sclerosis. Through international collaborative efforts involving tens of thousands of cases and controls, more than 100 associated common variants have now been identified. These variants consistently implicate genes associated with immunological processes, overwhelmingly lie in regulatory rather than coding regions, and are frequently associated with other autoimmune diseases. The functional implications of these associated variants are mostly unknown; however, early work has shown that several variants have effects on splicing that result in meaningful changes in the balance between different isoforms in relevant tissues. Including the well established risk attributable to variants in genes encoding human leucocyte antigens, only about a quarter of reported heritability can now be accounted for, suggesting that a substantial potential for further discovery remains.

引用

页码：700 / 709

页数：10

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