Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait

被引：144
作者：
Okuyama, Y
Ishiguro, H
Nankai, M
Shibuya, H
Watanabe, A
Arinami, T [1 ]
机构：
[1] Univ Tsukuba, Inst Basic Med Sci, Dept Med Genet, Tsukuba, Ibaraki 3058575, Japan
[2] Tokyo Metropolitan Police Hosp, Dept Neuropsychiat, Tokyo, Japan
[3] Tokyo Med & Dent Univ, Sch Med, Dept Neuropsychiat, Tokyo 113, Japan
来源：
MOLECULAR PSYCHIATRY | 2000年 / 5卷 / 01期
关键词：
temperament; linkage disequilibrium; dopamine;
D O I：
10.1038/sj.mp.4000563
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
polymorphism in the human dopamine D4 receptor gene (DRD4) exon III has been associated in some but not all studies of the human personality trait of Novelty Seeking. We searched for polymorphisms in the 5' region of DRD4 and identified six polymorphisms as follows: -1217G Ins/Del? -809G/A, -616C/G, -603T Ins/Del, -602(G)8-9, and -521C/T. Associations between these polymorphisms and personality traits measured by the Temperament and Character Inventory (TCI) were investigated in 86 healthy Japanese volunteers. The -521C/T polymorphism was significantly associated with Novelty Seeking (P = 0.0001). Subjects with the C/C genotype exhibited the highest Novelty Seeking scores and those with the T/T genotype exhibited the lowest. A transient expression method revealed that the T variant of the C-521T polymorphism reduces transcriptional efficiency. The present study suggests a contribution of dopamine D4 receptor availability to individual differences in Novelty Seeking behavior.
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收藏
页码：64 / 69
页数：6
相关论文
共 35 条
[1]   MODULATION OF INTRACELLULAR CYCLIC-AMP LEVELS BY DIFFERENT HUMAN DOPAMINE D4 RECEPTOR VARIANTS [J].
ASGHARI, V ;
SANYAL, S ;
BUCHWALDT, S ;
PATERSON, A ;
JOVANOVIC, V ;
VANTOL, HHM .
JOURNAL OF NEUROCHEMISTRY, 1995, 65 (03) :1157-1165
[2]   Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking [J].
Benjamin, J ;
Li, L ;
Patterson, C ;
Greenberg, BD ;
Murphy, DL ;
Hamer, DH .
NATURE GENETICS, 1996, 12 (01) :81-84
[3]   The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus [J].
Chang, FM ;
Kidd, JR ;
Livak, KJ ;
Pakstis, AJ ;
Kidd, KK .
HUMAN GENETICS, 1996, 98 (01) :91-101
[4]   Mapping genes for human personality [J].
Cloninger, CR ;
Adolfsson, R ;
Svrakic, NM .
NATURE GENETICS, 1996, 12 (01) :3-4
[5]  
CLONINGER CR, 1987, ARCH GEN PSYCHIAT, V44, P573
[6]   A PSYCHOBIOLOGICAL MODEL OF TEMPERAMENT AND CHARACTER [J].
CLONINGER, CR ;
SVRAKIC, DM ;
PRZYBECK, TR .
ARCHIVES OF GENERAL PSYCHIATRY, 1993, 50 (12) :975-990
[7]   Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking [J].
Ebstein, RP ;
Nemanov, L ;
Klotz, I ;
Gritsenko, I ;
Belmaker, RH .
MOLECULAR PSYCHIATRY, 1997, 2 (06) :472-477
[8]   Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking [J].
Ebstein, RP ;
Novick, O ;
Umansky, R ;
Priel, B ;
Osher, Y ;
Blaine, D ;
Bennett, ER ;
Nemanov, L ;
Katz, M ;
Belmaker, RH .
NATURE GENETICS, 1996, 12 (01) :78-80
[9]  
Grice DE, 1996, AM J HUM GENET, V59, P644
[10]   TESTING A MODEL FOR THE GENETIC-STRUCTURE OF PERSONALITY - A COMPARISON OF THE PERSONALITY SYSTEMS OF CLONINGER AND EYSENCK [J].
HEATH, AC ;
CLONINGER, CR ;
MARTIN, NG .
JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY, 1994, 66 (04) :762-775
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