Tolerating DNA damage during eukaryotic chromosome replication

被引：27

作者：

Saugar, Irene ^{[1
]}

Angeles Ortiz-Bazan, Maria ^{[1
]}

Antonio Tercero, Jose ^{[1
]}

机构：

[1] Ctr Biol Mol Severo Ochoa CSIC UAM, Madrid 28049, Spain

来源：

EXPERIMENTAL CELL RESEARCH | 2014年 / 329卷 / 01期

关键词：

Chromosome replication; DNA damage tolerance; Genome stability; TRANSLESION SYNTHESIS; UBIQUITIN LIGASE; POLYMERASE-ETA; ERROR-FREE; POSTREPLICATION REPAIR; TOLERANCE PATHWAY; MONOUBIQUITINATED PCNA; DVC1; C1ORF124; CELL-CYCLE; RECRUITS;

D O I：

10.1016/j.yexcr.2014.07.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In eukaryotes, the evolutionarily conserved RAD6/RAD18 pathway of DNA damage tolerance overcomes unrepaired DNA lesions that interfere with the progression of replication forks, helping to ensure the completion of chromosome replication and the maintenance of genome stability in every cell cycle. This pathway uses two different strategies for damage bypass:, translesion DNA synthesis, which is carried out by specialized polymerases that can replicate across the lesions, and DNA damage avoidance, a process that relies on a switch to an undamaged-DNA template for synthesis past the lesion. In this review, we summarise the current knowledge on DNA damage tolerance mechanisms mediated by RAD6/RAD18 that are used by eukaryotic cells to cope with DNA lesions during chromosome replication. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：170 / 177

页数：8

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