Tolerating DNA damage during eukaryotic chromosome replication

被引：27

作者：

Saugar, Irene ^{[1
]}

Angeles Ortiz-Bazan, Maria ^{[1
]}

Antonio Tercero, Jose ^{[1
]}

机构：

[1] Ctr Biol Mol Severo Ochoa CSIC UAM, Madrid 28049, Spain

来源：

EXPERIMENTAL CELL RESEARCH | 2014年 / 329卷 / 01期

关键词：

Chromosome replication; DNA damage tolerance; Genome stability; TRANSLESION SYNTHESIS; UBIQUITIN LIGASE; POLYMERASE-ETA; ERROR-FREE; POSTREPLICATION REPAIR; TOLERANCE PATHWAY; MONOUBIQUITINATED PCNA; DVC1; C1ORF124; CELL-CYCLE; RECRUITS;

D O I：

10.1016/j.yexcr.2014.07.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In eukaryotes, the evolutionarily conserved RAD6/RAD18 pathway of DNA damage tolerance overcomes unrepaired DNA lesions that interfere with the progression of replication forks, helping to ensure the completion of chromosome replication and the maintenance of genome stability in every cell cycle. This pathway uses two different strategies for damage bypass:, translesion DNA synthesis, which is carried out by specialized polymerases that can replicate across the lesions, and DNA damage avoidance, a process that relies on a switch to an undamaged-DNA template for synthesis past the lesion. In this review, we summarise the current knowledge on DNA damage tolerance mechanisms mediated by RAD6/RAD18 that are used by eukaryotic cells to cope with DNA lesions during chromosome replication. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：170 / 177

页数：8

共 66 条

[1] Causes of Genome Instability [J].

Aguilera, Andres ;

Garcia-Muse, Tatiana .

ANNUAL REVIEW OF GENETICS, VOL 47, 2013, 47 :1-+

[2] Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis [J].

Bienko, M ;

Green, CM ;

Crosetto, N ;

Rudolf, F ;

Zapart, G ;

Coull, B ;

Kannouche, P ;

Wider, G ;

Peter, M ;

Lehmann, AR ;

Hofmann, K ;

Dikic, I .

SCIENCE, 2005, 310 (5755) :1821-1824

[3] Regulation of Translesion Synthesis DNA Polymerase η by Monoubiquitination [J].

Bienko, Marzena ;

Green, Catherine M. ;

Sabbioneda, Simone ;

Crosetto, Nicola ;

Matic, Ivan ;

Hibbert, Richard G. ;

Begovic, Tihana ;

Niimi, Atsuko ;

Mann, Matthias ;

Lehmann, Alan R. ;

Dikic, Ivan .

MOLECULAR CELL, 2010, 37 (03) :396-407

[4] Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression [J].

Blastyák, Andras ;

Pintér, Lajos ;

Unk, Ildiko ;

Prakash, Louise ;

Prakash, Satya ;

Haracska, Lajos .

MOLECULAR CELL, 2007, 28 (01) :167-175

[5] Role of Double-Stranded DNA Translocase Activity of Human HLTF in Replication of Damaged DNA [J].

Blastyak, Andras ;

Hajdu, Ildiko ;

Unk, Ildiko ;

Haracska, Lajos .

MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (03) :684-693

[6] Regulation of DNA repair throughout the cell cycle [J].

Branzei, Dana ;

Foiani, Marco .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (04) :297-308

[7] SUMOylation regulates Rad18-mediated template switch [J].

Branzei, Dana ;

Vanoli, Fabio ;

Foiani, Marco .

NATURE, 2008, 456 (7224) :915-920

[8] Spartan/C1orf124, a Reader of PCNA Ubiquitylation and a Regulator of UV-Induced DNA Damage Response [J].

Centore, Richard C. ;

Yazinski, Stephanie A. ;

Tse, Alice ;

Zou, Lee .

MOLECULAR CELL, 2012, 46 (05) :625-635

[9] Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities [J].

Chang, Debbie J. ;

Lupardus, Patrick J. ;

Cimprich, Karlene A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (43) :32081-32088

[10] Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress [J].

Ciccia, Alberto ;

Nimonkar, Amitabh V. ;

Hu, Yiduo ;

Hajdu, Ildiko ;

Achar, Yathish Jagadheesh ;

Izhar, Lior ;

Petit, Sarah A. ;

Adamson, Britt ;

Yoon, John C. ;

Kowalczykowski, Stephen C. ;

Livingston, David M. ;

Haracska, Lajos ;

Elledge, Stephen J. .

MOLECULAR CELL, 2012, 47 (03) :396-409

← 1 2 3 4 5 6 7 →