Elastic vesicles as a tool for dermal and transdermal delivery

被引：35

作者：

Honeywell-Nguyen, P. Loan ^{[1
]}

Groenink, H. W. Wouter ^{[1
]}

Bouwstra, Joke A. ^{[1
]}

机构：

[1] Leiden Univ, Leiden Amsterdam Ctr Drug Res, Dept Drug Delivery Technol, NL-2300 RA Leiden, Netherlands

来源：

JOURNAL OF LIPOSOME RESEARCH | 2006年 / 16卷 / 03期

关键词：

elastic vesicles; transfersomes; skin; in vivo human skin interaction; transport studies;

D O I：

10.1080/08982100600848595

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The main problem in delivery of drugs across the skin is the barrier function of the skin, which is located in the outermost layer of the skin, the stratum corneum. The stratum corneum consists of corneocytes surrounded by lipid layers, the so-called lipid lamellae. When applying drugs onto the skin, the major penetration pathway is the tortuous intercellular route along the lipid lamellae. In order to increase the number of drugs administered via the transdermal route, novel drug delivery systems have to be designed. Among these systems are iontophoresis, electroporation, microneedles, and vesicular systems.

引用

页码：273 / 280

页数：8

共 11 条

[1]

[Anonymous], PREDICTION PERCUTANE

[2] LIPID VESICLES PENETRATE INTO INTACT SKIN OWING TO THE TRANSDERMAL OSMOTIC GRADIENTS AND HYDRATION FORCE [J].

CEVC, G ;

BLUME, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1104 (01) :226-232

[3] Transfersomes, liposomes and other lipid suspensions on the skin: Permeation enhancement, vesicle penetration, and transdermal drug delivery [J].

Cevc, G .

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 1996, 13 (3-4) :257-388

[4] Quantitative assessment of the transport of elastic and rigid vesicle components and a model drug from these vesicle formulations into human skin in vivo [J].

Honeywell-Nguyen, PL ;

Gooris, GS ;

Bouwstra, JA .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (05) :902-910

[5] Skin penetration and mechanisms of action in the delivery of the D2-agonist rotigotine from surfactant-based elastic vesicle formulations [J].

Honeywell-Nguyen, PL ;

Arenja, S ;

Bouwstra, JA .

PHARMACEUTICAL RESEARCH, 2003, 20 (10) :1619-1625

[6] The in vivo transport of elastic vesicles into human skin: effects of occlusion, volume and duration of application [J].

Honeywell-Nguyen, PL ;

Groenink, HWW ;

de Graaff, AM ;

Bouwstra, JA .

JOURNAL OF CONTROLLED RELEASE, 2003, 90 (02) :243-255

[7]

Honeywell-Nguyen PL, 2002, BBA-GEN SUBJECTS, V1573, P130

[8] Transdermal delivery of pergolide from surfactant-based elastic and rigid vesicles:: Characterization and in vitro transport studies [J].

Honeywell-Nguyen, PL ;

Frederik, PM ;

Bomans, PHH ;

Junginger, HE ;

Bouwstra, JA .

PHARMACEUTICAL RESEARCH, 2002, 19 (07) :991-997

[9] The in vitro transport of pergolide from surfactant-based elastic vesicles through human skin: a suggested mechanism of action [J].

Honeywell-Nguyen, PL ;

Bouwstra, JA .

JOURNAL OF CONTROLLED RELEASE, 2003, 86 (01) :145-156

[10] Interactions of elastic and rigid vesicles with human skin in vitro: electron microscopy and two-photon excitation microscopy [J].

van den Bergh, BAI ;

Vroom, J ;

Gerritsen, H ;

Junginger, HE ;

Bouwstra, JA .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1999, 1461 (01) :155-173

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