Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma

被引：68

作者：

Pesu, Marko ^{[1
]}

Muul, Linda ^{[1
]}

Kanno, Yuka ^{[1
]}

O'Shea, John J. ^{[1
]}

机构：

[1] NIH, MIIB, NIAMSD, Bethesda, MD 20892 USA

来源：

BLOOD | 2006年 / 108卷 / 03期

关键词：

D O I：

10.1182/blood-2005-09-3824

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin 12 (IL-12) is a major inducer of interleron gamma (IFN-gamma) and the principal mediator of T helper 1 (Th1) differentiation. To identify IL-12-regulated genes, which might contribute to Th1 differentiation and IFNG regulation, we employed microarray analysis. Surprisingly, a ubiquitously expressed proprotein convertase (PC), furin, was one of the most consistently IL-12-induced genes in T cells, and among PCs was the only one regulated by this cytokine. Furin was preferentially expressed in differentiated Th1 cells in a Stat4-dependent manner. Expression of furin enhanced IFN-gamma secretion, whereas inhibition of furin interfered with IFN-gamma production. Thus, we conclude that IL-12 induction of furin might represent a new aspect of IFN-gamma regulation and control of Th1 differentiation.

引用

页码：983 / 985

页数：3

共 24 条

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