Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET

被引：80

作者：

Kikuchi, Yasuka ^{[1
]}

Oyama-Manabe, Noriko ^{[1
]}

Naya, Masanao ^{[2
]}

Manabe, Osamu ^{[3
]}

Tomiyama, Yuuki ^{[3
]}

Sasaki, Tsukasa ^{[4
]}

Katoh, Chietsugu ^{[5
]}

Kudo, Kohsuke ^{[1
]}

Tamaki, Nagara ^{[3
]}

Shirato, Hiroki ^{[6
]}

机构：

[1] Hokkaido Univ Hosp, Dept Diagnost & Intervent Radiol, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Nucl Med, Sapporo, Hokkaido, Japan

[4] Hokkaido Univ Hosp, Dept Radiol, Sapporo, Hokkaido 0608638, Japan

[5] Hokkaido Univ, Fac Hlth Sci, Sapporo, Hokkaido, Japan

[6] Hokkaido Univ, Grad Sch Med, Dept Radiat Med, Sapporo, Hokkaido, Japan

来源：

EUROPEAN RADIOLOGY | 2014年 / 24卷 / 07期

关键词：

MDCT; Cardiac; Perfusion; Myocardium blood flow; Coronary flow reserve; TRANSTHORACIC DOPPLER-ECHOCARDIOGRAPHY; CORONARY-ARTERY-DISEASE; POSITRON-EMISSION-TOMOGRAPHY; COMPUTED-TOMOGRAPHY; DIAGNOSTIC PERFORMANCE; CORE320; MULTICENTER; VELOCITY RESERVE; DOSE REDUCTION; VOLUME CT; PERFUSION;

D O I：

10.1007/s00330-014-3164-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against O-15-H2O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients. Thirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs obtained by dynamic CTP and PET were compared between the validation group and CAD patients (n = 7). Correlation between MBF of MDCT and PET was strong (r = 0.95, P < 0.0001). CFR showed good correlation between dynamic CTP and PET (r = 0.67, P = 0.0126). CFRCT in the CAD group (2.3 +/- 0.8) was significantly lower than that in the validation group (5.2 +/- 1.8) (P = 0.0011). We established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT. Lower CFR was well demonstrated in CAD patients by dynamic CTP. aEuro cent MBF and CFR can be calculated using dynamic CTP with 320-row MDCT. aEuro cent MBF and CFR showed good correlation between dynamic CTP and PET. aEuro cent Lower CFR was well demonstrated in CAD patients by dynamic CTP.

引用

页码：1547 / 1556

页数：10

共 35 条

[1] Direct Comparison of Cardiac Magnetic Resonance and Multidetector Computed Tomography Stress-Rest Perfusion Imaging for Detection of Coronary Artery Disease [J].