Carapanins A-C: new limonoids from andiroba (Carapa guianensis) fruit oil

被引：0

作者：

Kikuchi, Takashi ^{[1
]}

Akita, Keiko ^{[1
]}

Koike, Hiroki ^{[1
]}

In, Yasuko ^{[1
]}

Yamada, Takeshi ^{[1
]}

Tanaka, Reiko ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, 4-20-1 Nasahara, Takatsuki, Osaka 5691094, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 45期

关键词：

GUIANOFRUITS;

D O I：

10.1039/d0ob01872d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carapanins A-C (1-3) were isolated from the fruit oil of Carapa guianensis. Compounds 1 and 2 are limonoids with unique structures. Namely, compound 1 is an andirobin-type limonoid with a C-15/C-30 gamma-lactone instead of the delta-lactone of the D-ring, and compound 2 is a mexicanolide-type limonoid with a C-16/C-30 delta-lactone ring. The absolute structures of 1 and 2 were determined using X-ray crystallography, whereas the structure of 3 was established mainly via NMR and mass spectroscopy. The inhibitory effects of 1-3 on nitric oxide production were evaluated, and it was revealed that 2 and 3 were potent nitric oxide inhibitors.

引用

页码：9268 / 9274

页数：7

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