CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers

[1] Albizu L, 2010, NAT CHEM BIOL, V6, P587, DOI [10.1038/NCHEMBIO.396, 10.1038/nchembio.396]

[2] Heteromeric MT1/MT2 Melatonin Receptors Modulate Photoreceptor Function [J]. SCIENCE SIGNALING, 2013, 6 (296)

[3] Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (02) : 743 - 748

[4] The apparent cooperativity of some GPCRs does not necessarily imply dimerization [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2009, 30 (04) : 182 - 187

[5] Cardiac muscarinic receptors. Cooperativity as the basis for multiple states of affinity [J]. BIOCHEMISTRY, 1997, 36 (24) : 7361 - 7379

[6] Fluorescent ligands to investigate GPCR binding properties and oligomerization [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2013, 41 : 148 - 153

[7] DELEAN A, 1980, J BIOL CHEM, V255, P7108

[8] Instability of a Class A G Protein-Coupled Receptor Oligomer Interface [J]. MOLECULAR PHARMACOLOGY, 2009, 75 (06) : 1296 - 1299

[9] Atomic-force microscopy: Rhodopsin dimers in native disc membranes [J]. NATURE, 2003, 421 (6919) : 127 - 128

[10] Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs [J]. CELL, 2011, 147 (05) : 1011 - 1023

[1] Albizu L, 2010, NAT CHEM BIOL, V6, P587, DOI [10.1038/NCHEMBIO.396, 10.1038/nchembio.396]

[2] Heteromeric MT1/MT2 Melatonin Receptors Modulate Photoreceptor Function [J]. SCIENCE SIGNALING, 2013, 6 (296)

[3] Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (02) : 743 - 748

[4] The apparent cooperativity of some GPCRs does not necessarily imply dimerization [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2009, 30 (04) : 182 - 187

[5] Cardiac muscarinic receptors. Cooperativity as the basis for multiple states of affinity [J]. BIOCHEMISTRY, 1997, 36 (24) : 7361 - 7379

[6] Fluorescent ligands to investigate GPCR binding properties and oligomerization [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2013, 41 : 148 - 153

[7] DELEAN A, 1980, J BIOL CHEM, V255, P7108

[8] Instability of a Class A G Protein-Coupled Receptor Oligomer Interface [J]. MOLECULAR PHARMACOLOGY, 2009, 75 (06) : 1296 - 1299

[9] Atomic-force microscopy: Rhodopsin dimers in native disc membranes [J]. NATURE, 2003, 421 (6919) : 127 - 128

[10] Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs [J]. CELL, 2011, 147 (05) : 1011 - 1023