Passive immunity in newborn from SARS-CoV-2-infected mother

被引：17

作者：

Cavaliere, Anna F. ^{[1
]}

Marchi, Laura ^{[1
]}

Aquilini, Donatella ^{[2
]}

Brunelli, Tamara ^{[3
]}

Vasarri, Pier L. ^{[4
]}

机构：

[1] Santo Stefano Hosp, AUSL Toscana Ctr, Obstet & Gynaecol Unit, Prato, Italy

[2] Santo Stefano Hosp, AUSL Toscana Ctr, Infect Dis Unit, Prato, Italy

[3] Santo Stefano Hosp, AUSL Toscana Ctr, Lab Anal, Microbiol Unit, Prato, Italy

[4] Santo Stefano Hosp, AUSL Toscana Ctr, Paediat & Neonatol Unit, Prato, Italy

来源：

JOURNAL OF MEDICAL VIROLOGY | 2021年 / 93卷 / 03期

关键词：

coronavirus; passive immunity; SARS‐ CoV‐ 2; vertical transmission; SYNDROME CORONAVIRUS 2; TRANSMISSION;

D O I：

10.1002/jmv.26609

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vertical transmission is an open issue. Recent reports call into question in utero or peripartum viral transmission to the offspring. Few data are available on immunoglobulin G (IgG) and/or IgM in newborns. Insufficient evidence is available regarding passive immunity in neonates born from SARS-CoV-2 infected women. We report a case of a neonate showing the presence of blood specific IgG and the absence of IgM and negative nasopharyngeal swab. He was born from an asymptomatic SARS-CoV-2-infected mother with positive IgG and IgM. The transplacental passage of specific IgG antibodies from the affected mother to the unaffected fetus highlights neonatal passive immunity.

引用

页码：1810 / 1813

页数：4

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