One-Pot Synthesis of Fused [1,6]Naphthyridine Derivatives via Three-Component Reaction

被引：2

作者：

Kumar, Adhiyaman Kottai Munusamy Magesh Selva ^{[1
]}

Dhivya, Paul ^{[1
]}

Rajendran, Subramanian Parameswaran ^{[1
]}

机构：

[1] Bharathiar Univ, Dept Chem, Coimbatore 641046, Tamil Nadu, India

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2017年 / 64卷 / 02期

关键词：

2-Chloroquinoline-4-amines; Aromatic aldehydes; Malononitrile; 5-Chloro-4-phenyl benzo[f][1,6]naphthyridine-2-amino-3-carbonitriles; EFFICIENT SYNTHESIS; MULTICOMPONENT REACTIONS; COMBINATORIAL SYNTHESIS; ROUTE; REARRANGEMENT; HETEROCYCLES; AAPTAMINE;

D O I：

10.1002/jccs.201600196

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, convenient, and eco-friendly synthetic protocol has been developed via a one-pot three-component reaction between 2-chloroquinoline-4-amines, different substituted aromatic aldehydes, and malononitrile using ethanol as reaction medium. Employing this protocol, a series of 5-chloro-4-phenyl benzo[f][1,6] naphthyridine-2-amino-3-carbonitrile derivatives were synthesized in an environmentally friendly approach under operational simplicity, short time reactions, easy work-up procedure, and comparatively high yields. This chemistry provides a convenient and promising synthetic strategy for the construction of the napthyridine skeleton. All synthesized compounds were identified on the basis of their spectral data.

引用

页码：138 / 142

页数：5

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