Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist:: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397)

被引：199

作者：

Kawamoto, H ^{[1
]}

Ozaki, S ^{[1
]}

Itoh, Y ^{[1
]}

Miyaji, M ^{[1
]}

Arai, S ^{[1
]}

Nakashima, H ^{[1
]}

Kato, T ^{[1
]}

Ohta, H ^{[1
]}

Iwasawa, Y ^{[1
]}

机构：

[1] Banyu Pharmaceut Co Ltd, Merck Res Labs, Banyu Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, Japan

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 42卷 / 25期

关键词：

D O I：

10.1021/jm990517p

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：5061 / 5063

页数：3

共 27 条

[1] [Phe1ψ(CH2-NH)Gly2]nociceptin-(1-13)-NH2 is an agonist of the nociceptin (ORL1) receptor [J].

Butour, JL ;

Moisand, C ;

Mollereau, C ;

Meunier, JC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 349 (01) :R5-R6

[2] Nociceptin, a novel endogenous ligand for the ORL1 receptor, has potent erectile activity in the cat [J].

Champion, HC ;

Wang, R ;

Hellstrom, WJG ;

Kadowitz, PJ .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1997, 273 (01) :E214-E219

[3]

CHAMPION HC, 1997, LIFE SCI, V60, P241

[4] MOLECULAR-CLONING, TISSUE DISTRIBUTION AND CHROMOSOMAL LOCALIZATION OF A NOVEL MEMBER OF THE OPIOID RECEPTOR GENE FAMILY [J].

CHEN, Y ;

FAN, Y ;

LIU, J ;

MESTEK, A ;

TIAN, MT ;

KOZAK, CA ;

YU, L .

FEBS LETTERS, 1994, 347 (2-3) :279-283

[5] Nociceptin stimulates locomotion and exploratory behaviour in mice [J].

Florin, S ;

Suaudeau, C ;

Meunier, JC ;

Costentin, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 317 (01) :9-13

[6] CDNA CLONING AND REGIONAL DISTRIBUTION OF A NOVEL MEMBER OF THE OPIOID RECEPTOR FAMILY [J].

FUKUDA, K ;

KATO, S ;

MORI, K ;

NISHI, M ;

TAKESHIMA, H ;

IWABE, N ;

MIYATA, T ;

HOUTANI, T ;

SUGIMOTO, T .

FEBS LETTERS, 1994, 343 (01) :42-46

[7] A new selective antagonist of the nociceptin receptor [J].

Guerrini, R ;

Calo, G ;

Rizzi, A ;

Bigoni, R ;

Bianchi, C ;

Salvadori, S ;

Regoli, D .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 (02) :163-165

[8]

GUMUSEL B, 1997, LIFE SCI, V60, P141

[9] Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress [J].

Jenck, F ;

Moreau, JL ;

Martin, JR ;

Kilpatrick, GJ ;

Reinscheid, RK ;

Monsma, FJ ;

Nothacker, HP ;

Civelli, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14854-14858

[10]

Kapusta DR, 1999, J PHARMACOL EXP THER, V289, P173

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