The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways involved in regulating synaptic functions.
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Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Beijing 100700, Peoples R ChinaFlorida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
Qiao, Haifa
Foote, Molly
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Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USAFlorida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
Foote, Molly
Graham, Kourtney
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Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USAFlorida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
Graham, Kourtney
Wu, Yuying
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Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USAFlorida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
Wu, Yuying
Zhou, Yi
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Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USAFlorida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
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Univ Alberta, Fac Med & Dent, Dept Med Genet & Signal Transduct Res Grp, Edmonton, AB T6G 2H7, CanadaUniv Alberta, Fac Med & Dent, Dept Med Genet & Signal Transduct Res Grp, Edmonton, AB T6G 2H7, Canada
Brandwein, Daniel
Wang, Zhixiang
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Univ Alberta, Fac Med & Dent, Dept Med Genet & Signal Transduct Res Grp, Edmonton, AB T6G 2H7, CanadaUniv Alberta, Fac Med & Dent, Dept Med Genet & Signal Transduct Res Grp, Edmonton, AB T6G 2H7, Canada
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Moscow MV Lomonosov State Univ, Dept Biochem, Fac Biol, Moscow 119991, RussiaMoscow MV Lomonosov State Univ, Dept Biochem, Fac Biol, Moscow 119991, Russia
Sluchanko, N. N.
Gusev, N. B.
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Moscow MV Lomonosov State Univ, Dept Biochem, Fac Biol, Moscow 119991, RussiaMoscow MV Lomonosov State Univ, Dept Biochem, Fac Biol, Moscow 119991, Russia