Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species

被引：231

作者：

Göker, H

Kus, C

Boykin, DW

Yildiz, S

Altanlar, N

机构：

[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

[3] Ankara Univ, Fac Pharm, Dept Microbiol, TR-06100 Ankara, Turkey

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0968-0896(02)00103-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New 2-substituted-phenyl-1H-benzimidazole-5-carboxylic acids (35, 38), ethyl-5-carboxylate (36), -5-carboxamides (37, 39),-5-carboxaldeliyde (42), -5-chloro (40), -5-trifluoromethyl (41), and -5-carbonitriles (44-53, 55-67), -6-carbonitrilc (54) were prepared and evaluated in vitro against Candida species. The cyano substituted compounds 53, 57, 58 and 61 exhibited the greatest activity with MIC values of 3.12 mug/mL, values similar to that of fluconazole. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2589 / 2596

页数：8

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