Liposomal Spherical Nucleic Acids

被引：173

作者：

Banga, Resham J. ^{[1
,2
]}

Chernyak, Natalia ^{[1
,3
]}

Narayan, Suguna P. ^{[1
,4
]}

Nguyen, SonBinh T. ^{[1
,3
]}

Mirkin, Chad A. ^{[1
,2
,3
]}

机构：

[1] Northwestern Univ, Int Inst Nanotechnol, Evanston, IL 60208 USA

[2] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL 60208 USA

[3] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[4] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 28期

基金：

美国国家卫生研究院;

关键词：

FUNCTIONALIZED GOLD NANOPARTICLES; INTRACELLULAR GENE-REGULATION; NANO-FLARES; DNA; STABILITY; MICELLES; DELIVERY; FUSION;

D O I：

10.1021/ja504845f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a tocopherol tail that intercalates into the phospholipid layer of the liposomal core via hydrophobic interactions. The spherical nucleic acid architecture not only stabilizes these constructs but also facilitates cellular internalization and gene regulation in SKOV-3 cells.

引用

页码：9866 / 9869

页数：4

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