Flow fine synthesis with heterogeneous catalysts

被引：160

作者：

Masuda, Koichiro ^{[1
]}

Ichitsuka, Tomohiro ^{[2
]}

Koumura, Nagatoshi ^{[2
]}

Sato, Kazuhiko ^{[2
]}

Kobayashi, Shu ^{[1
,2
]}

机构：

[1] Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[2] Natl Inst Adv Ind Sci & Technol, Interdisciplinary Res Ctr Catalyt Chem, Tsukuba, Ibaraki 3058565, Japan

来源：

TETRAHEDRON | 2018年 / 74卷 / 15期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

Flow fine synthesis; Heterogeneous catalyst; Continuous flow; Catalyst immobilization; CROSS-COUPLING REACTIONS; IONIC LIQUID-PHASE; MICROEMULSION-BASED ORGANOGELS; SUPPORTED PALLADIUM CATALYSTS; /MESOPOROUS SILICA MONOLITHS; CARBON BOND FORMATION; MINI-CONTINUOUS FLOW; ASYMMETRIC HYDROGENATION; HIGHLY EFFICIENT; SELECTIVE HYDROGENATION;

D O I：

10.1016/j.tet.2018.02.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the past few decades, organic reactions under flow conditions have attracted increasing attention. Flow reactions have a number of advantages over batch reactions in terms of environmental compatibility, efficiency, and safety. In particular, flow reactions with heterogeneous catalysts that yield desired products without significant levels of by-product formation can enable purification processes to be avoided. This feature can allow flow reactions to be assembled in a multi-step and continuous manner for the synthesis of complex molecules. These new techniques have opened up new approaches to the synthesis of fine chemicals and are expected to play a prominent role in future chemical manufacturing processes. In this context, this review aims to summarize recent developments in continuous-flow reactions with heterogeneous catalysts for synthesis of fine chemicals. (C) 2018 Published by Elsevier Ltd.

引用

页码：1705 / 1730

页数：26

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