Design, Synthesis and Biological Evaluation of Pazopanib Derivatives as Antitumor Agents

被引：53

作者：

Jia, Yuping ^{[1
]}

Zhang, Jian ^{[2
]}

Feng, Jinhong ^{[3
]}

Xu, Fuming ^{[2
]}

Pan, Huili ^{[2
]}

Xu, Wenfang ^{[2
]}

机构：

[1] Shandong Inst Pharmaceut Ind, Jinan 250101, Shandong, Peoples R China

[2] Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China

[3] Shandong Acad Sci, Shandong Anal & Test Ctr, Jinan 250012, Shandong, Peoples R China

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2014年 / 83卷 / 03期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

anti-angiogenesis; antitumor agent; pazopanib derivatives; synthesis; ENDOTHELIAL GROWTH-FACTOR; ANGIOGENESIS; INHIBITORS; MECHANISMS; THERAPY; KINASES; TARGET; CELLS;

D O I：

10.1111/cbdd.12243

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel series of pazopanib derivatives were designed, synthesized, and evaluated for their inhibitory activity against a series of kinases including VEGFR-2, EGFR, AKT1, ALK1, and ABL1. The anti-angiogenic activities ex vivo of some compounds were also investigated. Compounds P2d and P2e demonstrated outstanding inhibitory activity against VEGFR-2 and ABL1 and higher anti-angiogenic activity compared with Pazopanib, the reference standard. These two compounds (P2d and P2e) could be used as novel lead compounds for further development of anticancer agents.

引用

页码：306 / 316

页数：11

共 50 条

[21] Design, synthesis, and evaluation of methoxylated resveratrol derivatives as potential antitumor agents
Chen, Yuanmou
Hu, Fei
Gao, Yinghao
Jia, Shaolong
Ji, Na
Hua, Erbing
RESEARCH ON CHEMICAL INTERMEDIATES, 2015, 41 (05) : 2725 - 2738
[22] Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents
Zou, Hongbin
Zhang, Liang
Ouyang, Jingfeng
Giulianotti, Marc A.
Yu, Yongping
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (12) : 5970 - 5977
[23] Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents
Sabbah, Dima A.
Ibrahim, Ameerah H.
Talib, Wamidh H.
Alqaisi, Khalid M.
Sweidan, Kamal
Bardaweel, Sanaa K.
Sheikha, Ghassan A.
Zhong, Haizhen A.
Al-Shalabi, Eveen
Khalaf, Reema A.
Mubarak, Mohammad S.
MEDICINAL CHEMISTRY, 2019, 15 (04) : 417 - 429
[24] Design, synthesis, and biological evaluation of novel 4-phenoxypyridine derivatives as potential antitumor agents
Liu, Ju
Liu, Yutong
Hao, Xuechen
Wang, Yang
Ji, Jingchao
Liu, Yajing
Ding, Shi
Chen, Ye
ARCHIV DER PHARMAZIE, 2019, 352 (05)
[25] Design, synthesis and biological evaluation of C(6)-indole celastrol derivatives as potential antitumor agents
Tang, Kaiyong
Huang, Jinwen
Pan, Junfang
Zhang, Xuan
Lu, Wei
RSC ADVANCES, 2015, 5 (25) : 19620 - 19623
[26] Design, synthesis and biological evaluation of novel furoxan-based coumarin derivatives as antitumor agents
Zhuo Zhang
Zhi-Wei Bai
Yong Ling
Li-Qin He
Peng Huang
Hong-Xia Gu
Rong-Feng Hu
Medicinal Chemistry Research, 2018, 27 : 1198 - 1205
[27] Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents
Ma Junjie
Hu Gang
Xie Lijun
Chen Lei
Xu Boxuan
Gong Ping
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2015, 31 (06) : 958 - 963
[28] Design, Synthesis, and Biological Evaluation of N-Aryl-salicylamide Derivatives as Potential Antitumor Agents
Wang, Jie
Wu, Hao
Li, Jiaming
Xu, Qinlong
He, Guangwei
Zhong, Guochen
Zhang, Yanchun
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2013, 33 (05) : 1026 - 1034
[29] Design, synthesis and biological evaluation of novel furoxan-based coumarin derivatives as antitumor agents
Zhang, Zhuo
Bai, Zhi-Wei
Ling, Yong
He, Li-Qin
Huang, Peng
Gu, Hong-Xia
Hu, Rong-Feng
MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (04) : 1198 - 1205
[30] Design, Synthesis and Biological Evaluation of Novel 4-Substituted Coumarin Derivatives as Antitumor Agents
An, Ran
Hou, Zhuang
Li, Jian-Teng
Yu, Hao-Nan
Mou, Yan-Hua
Guo, Chun
MOLECULES, 2018, 23 (09):

← 1 2 3 4 5 →