Molecular tools for the construction of peptide-based materials

被引：96
作者：
Ramakers, B. E. I. [1 ]
van Hest, J. C. M. [1 ]
Lowik, D. W. P. M. [1 ]
机构：
[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands
来源：
CHEMICAL SOCIETY REVIEWS | 2014年 / 43卷 / 08期
关键词：
SOLID-PHASE SYNTHESIS; STAUDINGER LIGATION; MULTIVALENT PEPTIDE; BLOCK-COPOLYMERS; GENERAL-METHOD; HYDROGELS; POLYPEPTIDE; ATRP; NANOPARTICLES; CHEMISTRY;
D O I：
10.1039/c3cs60362h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Proteins and peptides are fundamental components of living systems where they play crucial roles at both functional and structural level. The versatile biological properties of these molecules make them interesting building blocks for the construction of bio-active and biocompatible materials. A variety of molecular tools can be used to fashion the peptides necessary for the assembly of these materials. In this tutorial review we shall describe five of the main techniques, namely solid phase peptide synthesis, native chemical ligation, Staudinger ligation, NCA polymerisation, and genetic engineering, that have been used to great effect for the construction of a host of peptide-based materials.
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收藏
页码：2743 / 2756
页数：14
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