Synchronisation in the beta frequency-band - The bad boy of parkinsonism or an innocent bystander?

被引：101
作者：
Eusebio, Alexandre [1 ,2 ]
Brown, Peter [1 ]
机构：
[1] Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
[2] CHU Timone, Dept Neurol & Movement Disorders, Marseille, France
来源：
EXPERIMENTAL NEUROLOGY | 2009年 / 217卷 / 01期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
DEEP BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS; BASAL GANGLIA; OSCILLATORY ACTIVITY; PATHOLOGICAL SYNCHRONIZATION; CEREBRAL-CORTEX; DISEASE; DOPAMINE; MOVEMENT; BRADYKINESIA;
D O I：
10.1016/j.expneurol.2009.02.003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Excessive synchronisation of basal ganglia neuronal activity in the beta frequency band has been implicated in Parkinson's disease. In a recent issue of Experimental Neurology, Bronte-Stewart, H., Barberini, C., Koop, M. M., Hill, B.C., Henderson, J.M., Wingeier, B., 2009. The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain Stimulation. Exp. Neurol. 215, 20-28. demonstrate that such activity is consistent over time and provide further evidence that deep brain stimulation is associated with its Suppression. However, the extent to which beta synchrony has a mechanistic (rather than epiphenomenal) role in parkinsonism remains unclear, and the suppression of this activity by deep brain Stimulation is contentious. This commentary discusses the evidence for and against a role for excessive beta synchrony in mediating the parkinsonian phenotype and in providing a possible mechanism to explain the therapeutic effects of deep brain stimulation in Parkinson's disease. (C) 2009 Elsevier Inc. All rights reserved.
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页码：1 / 3
页数：3
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