Potentiation of the anti-HIV activity of zalcitabine and lamivudine by a CTP synthase inhibitor, 3-deazauridine

被引：24
作者：
Gao, WY
Johns, DG [1 ]
Mitsuya, H
机构：
[1] NCI, Med Chem Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA
[2] NCI, Expt Retrovirol Sect, Med Branch, Div Clin Sci,NIH, Bethesda, MD 20892 USA
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2000年 / 19卷 / 1-2期
关键词：
D O I：
10.1080/15257770008033015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Low levels of the CTP synthase inhibitor 3-deazauridine (3-DU) strongly potentiated the anti-HLV-1 activity of the 5'-triphosphates of the cytidine-based analogues [-]2'-deoxy-3'-thiacytidine (3TC; lamivudine) and 2',3'-dideoxycytidine (ddC). The potentiation was associated with a 3-DU-induced decrease in dCTP pool size; no changes were seen in cellular pool sizes of dATP, dGTP or dTTP.
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页码：371 / 377
页数：7
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