Sequence-specific nucleic acid damage induced by peptide nucleic acid conjugates that can be enzyme-activated

被引：5
作者：
Simon, Philippe
Decout, Jean-Luc
Fontecave, Marc
机构：
[1] Univ Grenoble 1, UMR 5063, CNRS, Dept Pharmacochim Mol, F-38240 Meylan, France
[2] Univ Grenoble 1, CNRS, CEA,Ctr Redox Biol, UMR 5047,Lab Chim & Biochim, F-38054 Grenoble 9, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 41期
关键词：
DNA damage; enzymes; flavins; oligonucleotides; oxidoreductases;
D O I：
10.1002/anie.200601681
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Recruitment drive: A 12 mer peptide nucleic acid(PNA)-flavin conjugate is prepared. When the PNA moiety is hybridized to its complementary sequence in a 25 mer oligo-2′-deoxyribonucleotide, the flavin moiety can recruit an NADPH:flavin oxidoreductase. This complex allows the activation of molecular oxygen in the presence of NADH and the selective oxidation of the oligonucleotide target (see scheme). (Figure Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：6859 / 6861
页数：3
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