1,3-Diphenylpyrazoles: synthesis and antiparasitic activities of azomethine derivatives

被引：200
作者：
Rathelot, P
Azas, N
El-Kashef, H
Delmas, F
Di Giorgio, C
Timon-David, P
Maldonado, J
Vanelle, P
机构：
[1] Fac Pharm Marseille, Chim Organ Lab, CNRS, UMR 6517, F-13385 Marseille 5, France
[2] Fac Pharm Marseille, EA 864, Parasitol Lab, F-13385 Marseille, France
[3] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 37卷 / 08期
关键词：
diphenylpyrazole; nitrophenylpyrazole; azomethine; antiplasmodial activity; trichmonocidal activity; leishmanicidal activity;
D O I：
10.1016/S0223-5234(02)01388-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
1,3-Diphenylpyrazole-4-carboxaldehyde and 1-(4-nitrophenyl)-3-phenylpyrazole-4-carboxaldehyde were obtained from the appropriated phenylhydrazones via the Vilsmeier-Haack reaction. These two aldehydes were functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed. In the most cases, nitrated compounds were found to be more efficient than non-nitrated ones against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.
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页码：671 / 679
页数：9
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