A convenient synthesis of 1,4-disubstituted imidazoles

被引：35
|
作者：
He, Y [1 ]
Chen, YZ [1 ]
Du, HW [1 ]
Schmid, LA [1 ]
Lovely, CJ [1 ]
机构：
[1] Univ Texas, Dept Chem & Biochem, Arlington, TX 76019 USA
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 28期
基金：
美国国家卫生研究院;
关键词：
imidazoles; regioselective; protection; isomerization;
D O I：
10.1016/j.tetlet.2004.05.011
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the regioselective protection of 4-alkyl-, 4-iodo, 4-vinylimidazoles has been developed via all alkylation-isomerization sequence with various imidazole-protecting groups. The initially formed mixture of 4/5-alkyl-, 4/5-iodo, and 4/5-vinylimidazoles are isomerized to the corresponding 4-isomers on treatment of a DMF solution with a small amount of RX and heating at 75degreesC. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5529 / 5532
页数：4
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