One-pot Synthesis of Hollongdione from Dipterocarpol

被引：0

作者：

Smirnova, Irina E. ^{[1
]}

Kazakova, Oxana B. ^{[1
]}

Do Thi Thu Huong ^{[2
]}

Minnibaeva, El'za M. ^{[1
]}

Lobov, Alexandr N. ^{[1
]}

Suponitsky, Kiryll Yu. ^{[3
]}

机构：

[1] Russian Acad Sci, Ufa Res Ctr, Inst Organ Chem, Ufa 450054, Russia

[2] Vietnamese Acad Sci, Inst Chem, Hanoi, Vietnam

[3] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia

来源：

NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Natural products; Dammarane triterpenoids; Dipterocarpol; Pregnane steroids; Oxidation; Ozone; X-ray analysis; Antibacterial activity; ACID-DERIVATIVES; BIOLOGICAL EVALUATION; OZONOLYSIS; TRITERPENOIDS; DAMMARANE; PRODUCT;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A one-pot synthesis of a hybrid triterpenoid-steroid molecule, hollongdione (22,23,24,25,26,27-hexanordammar-3,20-dion), was achieved in a yield of 89%, based on the selective dehydration of dipterocarpol following ozonolysis. The structure of hollongdione was confirmed by X-ray analysis for the first time. Dammar-20(22),24(25)-dien inhibited the growth of Mycobacterium tuberculosis (strain H37Rv) in vitro with a MIC of 50 mu g/mL.

引用

页码：1417 / 1420

页数：4