Phospholipid-based multifunctional coating via layer-by-layer self-assembly for biomedical applications

被引：12

作者：

Li, Peichuang ^{[1
,2
]}

Li, Xiaojing ^{[1
,2
]}

Cai, Wanhao ^{[3
]}

Chen, Huiqing ^{[1
,2
]}

Chen, Hang ^{[1
,2
]}

Wang, Rui ^{[1
,2
]}

Zhao, Yuancong ^{[1
,2
]}

Wang, Jin ^{[1
,2
]}

Huang, Nan ^{[1
,2
]}

机构：

[1] Southwest Jiaotong Univ, Educ Minist, Key Lab Adv Technol Mat, Chengdu 610031, Peoples R China

[2] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China

[3] Albert Ludwigs Univ Freiburg, Inst Phys Chem, Albertstr 23a, D-79104 Freiburg, Germany

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2020年 / 116卷

基金：

中国国家自然科学基金;

关键词：

Phospholipid; Type I collagen; REDV; Layer-by-layer; Blood-contacting; DOPAMINE-ASSISTED IMMOBILIZATION; TRANSFER RADICAL POLYMERIZATION; DRUG-ELUTING STENTS; INTERVENTIONAL THERAPY; SURFACE MODIFICATION; TITANIUM; ENDOTHELIALIZATION; RESTENOSIS; FILM; HEMOCOMPATIBILITY;

D O I：

10.1016/j.msec.2020.111237

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

As an important class of biomaterials,bionics inspired materials has been widely used in creating extracorporeal and implantable medical devices. However, specific service environment is often faced with multiple requirements rather than single function. Herein, we designed a phospholipid-based multifunctional coating with phospholipids-based polymers, type I collagen (Col-I) and Arg-Glu-Asp-Val (REDV) peptide, via layer-by-layer assembly. The successful synthesis of the polymers and the coating is proved by a series of characterization methods including Fourier transforming infrared spectra (FTIR), proton nuclear magnetic resonance (H-1 NMR), ultraviolet-visible spectra (UV) and X-ray photoelectron spectroscopy (XPS), while the assembly process and quality change of the coating were monitored via quartz crystal microbalance (QCM). Besides, hydrophilicity and roughness of this coating was analyzed via water contact angle (WCA) and atomic force microscope (AFM), respectively. Finally, results from platelet adhesion, activation assay, smooth muscle cells (SMCs) and endothelial cells (ECs) cultures indicated that the multifunctional coating could strongly inhibit platelet adhesion and SMCs proliferation, hence provide practical application of the coating with good biocompatibility, especially the anticoagulant property and cell compatibility. It is expected that this coating may be used in blood-contacting fields such as cardiovascular stent or other devices in the future.

引用

页数：12

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