Selective synthesis of 3-methyleneindolin-2-ones by one-pot multicatalytic processes

被引：26

作者：

Song, Ren-Jie ^{[1
]}

Liu, Yu ^{[1
]}

Li, Rong-Jiang ^{[1
]}

Li, Jin-Heng ^{[1
]}

机构：

[1] Hunan Normal Univ, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Hunan, Peoples R China

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 27期

基金：

中国国家自然科学基金;

关键词：

Copper; Palladium; Amination; C-H functionalization; Propiolamide; 3-Methyleneindolin-2-one; EFFICIENT COPPER CATALYST; GROWTH-FACTOR RECEPTOR; C-H FUNCTIONALIZATION; ARYL HALIDES; STEREOSELECTIVE-SYNTHESIS; DOMINO REACTIONS; TYROSINE KINASE; AMIDATION; TANDEM; DISCOVERY;

D O I：

10.1016/j.tetlet.2009.04.066

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel one-pot multicatalytic route for the synthesis of 3-methyleneindolin-2-ones has been developed involving sequential copper-catalyzed amination and palladium-catalyzed C-H functionalization processes. In the presence of CuI and Pd(OAc)(2), a variety of propiolamides underwent the reaction with iodides to afford the corresponding 3-methyleneindolin-2-ones in moderate yields. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3912 / 3916

页数：5

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