Predictors of mortality in non-neutropenic patients with invasive pulmonary aspergillosis: does galactomannan have a role?

被引：19

作者：

Russo, Alessandro ^{[1
]}

Giuliano, Simone ^{[1
]}

Vena, Antonio ^{[1
]}

Lucidi, Cristina ^{[2
]}

Falcone, Marco ^{[1
]}

Raponi, Giammarco ^{[1
]}

Merli, Manuela ^{[2
]}

Venditti, Mario ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Policlin Umberto 1, Dept Publ Hlth & Infect Dis, Rome, Italy

[2] Univ Roma La Sapienza, Policlin Umberto 1, Dept Clin Med, Rome, Italy

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2014年 / 80卷 / 01期

关键词：

Invasive pulmonary aspergillosis; Chronic obstructive pulmonary disease; Cirrhosis; Galactomannan; Bronchoalveolar lavage; CELL TRANSPLANT RECIPIENTS; CRITICALLY-ILL PATIENTS; CLINICAL-PRACTICE; RISK-FACTORS; DISEASE; INFECTIONS;

D O I：

10.1016/j.diagmicrobio.2014.05.015

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We aimed to investigate the role of several host factors as predictors of mortality in non-neutropenic patients with invasive pulmonary aspergillosis (IPA). Contribution of respiratory galactomannan (GM) index was evaluated as well. In this retrospective study, we examined 27 patients with "proven" and "probable" IPA. Outcome measured was death within 6-week from diagnosis of possible IPA. Overall mortality was 33.3%. At univariate analysis, nonsurvivors were statistically more likely to be affected with cirrhosis. No independent variables predicting mortality were identified in the multivariate model. Mean bronchoalveolar lavage (BAL) GM index value in the nonsurvivor group was significantly higher. A GM index cutoff value >= 2.0 is able to classify patients with a poor outcome with a sensitivity of 100% and a specificity of 77%. Liver cirrhosis is a predictor of mortality in patients with IPA. GM index in BAL might be considered as a valuable tool in classifying patients at risk of poor outcome. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：83 / 86

页数：4

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