Presence and Persistence of Zika Virus RNA in Semen, United Kingdom, 2016

被引：79

作者：

Atkinson, Barry ^{[1
]}

Thorburn, Fiona ^{[1
,2
]}

Petridou, Christina ^{[1
,3
,4
]}

Bailey, Daniel ^{[1
]}

Hewson, Roger ^{[1
]}

Simpson, Andrew J. H. ^{[1
]}

Brooks, Timothy J. G. ^{[1
]}

Aarons, Emma J. ^{[1
]}

机构：

[1] Publ Hlth England, Porton Down, England

[2] West Scotland Specialist Virol Ctr, Glasgow, Lanark, Scotland

[3] Hampshire Hosp Natl Hlth Serv Fdn Trust, Basingstoke, Hants, England

[4] Hampshire Hosp Natl Hlth Serv Fdn Trust, Winchester, Hants, England

来源：

EMERGING INFECTIOUS DISEASES | 2017年 / 23卷 / 04期

关键词：

SEXUAL TRANSMISSION; CROSS-REACTIVITY; INFECTION; EPIDEMIC; STATES;

D O I：

10.3201/eid2304.161692

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Zika virus RNA has been detected in semen collected several months after onset of symptoms of infection. Given the potential for sexual transmission of Zika virus and for serious fetal abnormalities resulting from infection during pregnancy, information regarding the persistence of Zika virus in semen is critical for advancing our understanding of potential risks. We tested serial semen samples from symptomatic male patients in the United Kingdom who had a diagnosis of imported Zika virus infection. Among the initial semen samples from 23 patients, Zika virus RNA was detected at high levels in 13 (56.5%) and was not detected in 9 (39.1%); detection was indeterminate in 1 sample (4.4%). After symptomatic infection, a substantial proportion of men have detectable Zika virus RNA at high copy numbers in semen during early convalescence, suggesting high risk for sexual transmission. Viral RNA clearance times are not consistent and can be prolonged.

引用

页码：611 / 615

页数：5

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