Diabetic peripheral neuropathy: Amelioration of pain with transcutaneous electrostimulation

被引:117
作者
Kumar, D
Marshall, HJ
机构
[1] UNIV SO CALIF,LOS ANGELES CTY MED CTR,DEPT MED,LOS ANGELES,CA 90033
[2] UNIV SO CALIF,LOS ANGELES CTY MED CTR,PODIATRY DEPT,LOS ANGELES,CA 90033
关键词
D O I
10.2337/diacare.20.11.1702
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE-To evaluate the efficacy of transcutaneous electrotherapy for chronic painful peripheral neuropathy in patients with type Z diabetes. RESEARCH DESIGN AND METHODS-Thirty-one patients with symptoms and signs of peripheral neuropathy were randomized to the electrotherapy or sham treatment (control) group. The electrostimulation was given by a portable unit (II-Wave machine) that generated a biphasic, exponentially decaying waveform (pulse width 4 ms, 25-35 V, greater than or equal to 2 Hz). Patients treated each of their lower extremities for 30 min daily for 4 weeks at home. Nine patients from the sham-treatment group participated for a second period, during which all of them received the active electrotherapy. Patient's degree of pain and discomfort was graded on a scale of 0 to 5. RESULTS-In the sham-treated group (n = 13), the neuropathic symptoms improved in five (38%) patients, and the pain score declined from 2.92 +/- 0.13 to 2.38 +/- 0.26 (P < 0.04), suggesting a procedure-related placebo effect. In the electrotherapy group (n = 18), symptomatic improvement was seen in 15 (83%) cases, 3 of which were completely asymptomatic; the pain score declined from 3.17 +/- 0.12 to 1.44 +/- 0.25 (P < 0.01) and the posttreatment pain scores were considerably lower (P < 0.03), indicating a substantial treatment effect over and above any placebo influence. Patients in the electrotherapy group reported greater reduction in symptoms (52 +/- 7% vs. 27 +/- 10% in control subjects, P < 0.05) on an analog scale. Moreover, the electrotherapy decreased pain scores (from 3.0 +/- 0.62 to 1.56 +/- 0.32, P < 0.02) in nine patients who had received sham treatment earlier. CONCLUSIONS-A form of transcutaneous electrotherapy ameliorated the pain and discomfort associated with peripheral neuropathy. This novel modality offers a potential nonpharmacological treatment option.
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收藏
页码:1702 / 1705
页数:4
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