Catalytic Asymmetric Synthesis of Chiral 2-Vinylindole Scaffolds by Friedel-Crafts Reaction

被引：19
作者：
Arai, Takayoshi [1 ]
Tsuchida, Akiko
Miyazaki, Tomoya
Awata, Atsuko
机构：
[1] Chiba Univ, Mol Chiral Res Ctr, Grad Sch Sci, Inage, Chiba 2638522, Japan
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 04期
关键词：
DIELS-ALDER REACTIONS; DIPHENYLAMINE-LINKED BIS(OXAZOLINE); SELECTIVE 3+2 CYCLOADDITION; NITRO-MANNICH REACTION; ENANTIOSELECTIVE SYNTHESIS; FUNCTIONALIZED TETRAHYDROCARBAZOLES; ALKYLATION REACTIONS; INDOLE-DERIVATIVES; IMINO ESTERS; NITROALKENES;
D O I：
10.1021/acs.orglett.6b03584
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A chiral bis(imidazolidine)pytidine (PyBidine) -Ni(OTF)(2) complex smoothly catalyzed an asymmetric Friedel Crafts reaction of 2-vinylindoles with nitroalkenes to give chiral indoles in a highly enantioselective manner while maintaining the 2-vinyl functionality. the chiral 2-vinylindoles offer unique chiral scaffolds for diverse transformations.
引用
收藏
页码：758 / 761
页数：4
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