microRNA: A Promising Diagnostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma

被引：35
|
作者：
Li, Xiaofei [1 ]
Yang, Wenjun [2 ,3 ]
Lou, Lianqing [1 ]
Chen, Yongxin [1 ]
Wu, Shuang [1 ]
Ding, Guoqiang [1 ]
机构：
[1] YiWu Cent Hosp, Dept Infect Dis, Yiwu 322000, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pharm,Binjiang Hosp, Hangzhou 310009, Zhejiang, Peoples R China
[3] Binjiang Hosp Hangzhou, Dept Pharm, Hangzhou 310009, Zhejiang, Peoples R China
来源：
DIGESTIVE DISEASES AND SCIENCES | 2014年 / 59卷 / 06期
关键词：
miRNAs; Diagnostic markers; Prognostic markers; Hepatocellular carcinoma; HEPATITIS-C VIRUS; REGULATES G(1)/S TRANSITION; INTERFERON-ALPHA; DOWN-REGULATION; SUPPRESSES TUMORIGENICITY; CELL-MIGRATION; VIRAL VECTORS; LIVER-CANCER; GENE-THERAPY; IN-VIVO;
D O I：
10.1007/s10620-013-3006-1
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
microRNAs constitute a novel class of small, non-coding RNAs that negatively regulate gene expression via translational inhibition or mRNA degradation. Aberrant miRNA expression has been implicated in the initiation, progression, and metastasis of hepatocellular carcinoma (HCC). It is well-documented that miRNAs function as either tumor suppressor genes or oncogenes in the development and progression of HCC. Additionally, substantial evidence suggests that unique miRNA signatures can serve as valuable diagnostic and prognostic biomarkers for HCC. Interestingly, certain subsets of miRNAs have also been identified as potential therapeutic targets for HCC.
引用
收藏
页码：1099 / 1107
页数：9
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