Pathology of Pulmonary Hypertension

被引：134
|
作者：
Tuder, Rubin M. [1 ]
Stacher, Elvira [2 ,3 ]
Robinson, Jeffrey [1 ]
Kumar, Rahul [1 ]
Graham, Brian B. [1 ]
机构：
[1] Univ Colorado, Sch Med, Div Pulm Sci & Crit Care Med, Program Translat Lung Res,Dept Med, Aurora, CO 80045 USA
[2] Med Univ Graz, Inst Pathol, A-8010 Graz, Austria
[3] Ludwig Boltzmann Inst Lung Vasc Res, A-8010 Graz, Austria
来源：
CLINICS IN CHEST MEDICINE | 2013年 / 34卷 / 04期
关键词：
Pulmonary hypertension; Smooth muscle cells; Endothelial cells; Angiogenesis; Vascular remodeling; PLEXIFORM LESIONS; CELL PROLIFERATION; ARTERIES; INFLAMMATION; HYPOXIA; INVOLVEMENT; MORPHOMETRY; MUTATIONS; CYTOKINES; SURVIVAL;
D O I：
10.1016/j.ccm.2013.08.009
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The pathology of pulmonary hypertension includes numerous abnormalities of the intima, media, and adventitia of the pulmonary vascular tree. A recently completed systematic analysis revealed high variability of morphologic measurements within a given pulmonary arterial hypertension (PAH) lung and among all PAH lungs, as well as distinct pathologic subphenotypes, and included a subset of lungs lacking intimal and medial remodeling. There was correlation between perivascular inflammation, remodeling, and hemodynamics. This article summarizes the pathologic features of the normal and abnormal pulmonary circulation, and correlations with animal models.
引用
收藏
页码：639 / +
页数：13
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