cDNA cloning and characterization of porcine histamine H4 receptor

被引：35
作者：
Oda, T
Matsumoto, S
Masuho, Y
Takasaki, J
Matsumoto, M
Kamohara, M
Saito, T
Ohishi, T
Soga, T
Hiyama, H
Matsushime, H
Furuichi, K
机构：
[1] Yamanouchi Pharmaceut Co Ltd, Mol Med Lab, Inst Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
[2] Helix Res Inst Inc, Chiba 2920812, Japan
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2002年 / 1575卷 / 1-3期
关键词：
histamine; H4; receptor; GPCR; ortholog; porcine; cDNA cloning;
D O I：
10.1016/S0167-4781(02)00236-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cDNA encoding histamine H4 receptor was cloned from the porcine spleen cDNA library. Porcine H4 receptor, which shares 72% homology with its human counterpart. bound to histamine in receptor-expressing mammalian cells. Isolation of the porcine H4 receptor, which is important for understanding of the pharmacology, will aid in better interpretation of physiological role of this subtype of histamine receptor. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：135 / 138
页数：4
相关论文
共 11 条
  • [1] Hill SJ, 1997, PHARMACOL REV, V49, P253
  • [2] Liu CL, 2001, J PHARMACOL EXP THER, V299, P121
  • [3] Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow
    Liu, CL
    Ma, XJ
    Jiang, XX
    Wilson, SJ
    Hofstra, CL
    Blevitt, J
    Pyati, J
    Li, XB
    Chai, WY
    Carruthers, N
    Lovenberg, TW
    [J]. MOLECULAR PHARMACOLOGY, 2001, 59 (03) : 420 - 426
  • [4] Cloning and functional expression of the human histamine H3 receptor
    Lovenberg, TW
    Roland, BL
    Wilson, SJ
    Jiang, XX
    Pyati, J
    Huvar, A
    Jackson, MR
    Erlander, MG
    [J]. MOLECULAR PHARMACOLOGY, 1999, 55 (06) : 1101 - 1107
  • [5] Morse KL, 2001, J PHARMACOL EXP THER, V296, P1058
  • [6] Molecular cloning and characterization of a new human histamine receptor, HH4R
    Nakamura, T
    Itadani, H
    Hidaka, Y
    Ohta, M
    Tanaka, K
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 279 (02) : 615 - 620
  • [7] Discovery of a novel member of the histamine receptor family
    Nguyen, T
    Shapiro, DA
    George, SR
    Setola, V
    Lee, DK
    Cheng, R
    Rauser, L
    Lee, SP
    Lynch, KR
    Roth, BL
    O'Dowd, BF
    [J]. MOLECULAR PHARMACOLOGY, 2001, 59 (03) : 427 - 433
  • [8] Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes
    Oda, T
    Morikawa, N
    Saito, Y
    Masuho, Y
    Matsumoto, S
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) : 36781 - 36786
  • [9] SCHWORER H, 1994, N-S ARCH PHARMACOL, V350, P375
  • [10] Takasaki J, 2001, MOL PHARMACOL, V60, P432
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