Therapeutic monoclonal antibodies in human breast milk: a case study

被引：10

作者：

Ross, Elle ^{[1
]}

Robinson, Steven E. ^{[1
]}

Amato, Carol ^{[1
]}

McMillan, Colette ^{[1
]}

Westcott, Jay ^{[1
]}

Wolf, Tiffany ^{[1
]}

Robinson, William A. ^{[1
]}

机构：

[1] Univ Colorado, Div Med Oncol, Sch Med, Melanoma Res Program, Aurora, CO USA

来源：

MELANOMA RESEARCH | 2014年 / 24卷 / 02期

关键词：

monoclonal antibodies; breast milk; melanoma; melanoma therapy; INFLAMMATORY-BOWEL-DISEASE; METASTATIC MELANOMA; NURSING MOTHERS; IMMUNE-SYSTEM; SAFETY; IPILIMUMAB; INFLIXIMAB; PREGNANCY; COLOSTRUM;

D O I：

10.1097/CMR.0000000000000047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, therapeutic monoclonal antibodies have been introduced for the treatment of advanced melanoma and other diseases. It remains unclear whether these drugs can be safely administered to women who are breast feeding because of the potential hazardous side effects for nursing infants. One such therapy for metastatic melanoma is ipilimumab, a human monoclonal antibody that blocks cytotoxic T-lymphocyte-antigen-4, and is the preferred treatment for patients with metastatic melanoma when other molecular therapies are not viable. This study measured ipilimumab levels in the breast milk of a patient undergoing treatment that were enough to raise concerns for a nursing infant exposed to ipilimumab.

引用

页码：177 / 180

页数：4

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