共 33 条
Nucleocytoplasmic Traffic of CPEB1 and Accumulation in Crm1 Nucleolar Bodies
被引:38
作者:

Ernoult-Lange, Michele
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机构:
Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France

Wilczynska, Ania
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机构:
Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France
Warsaw Canc Ctr, Dept Mol Biol, PL-02781 Warsaw, Poland Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France

Harper, Maryannick
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Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France

Aigueperse, Christelle
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机构:
Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France

Dautry, Francois
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Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France

Kress, Michel
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机构:
Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France

Weil, Dominique
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h-index: 0
机构:
Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France
机构:
[1] Inst Andre Lwoff, CNRS, FRE2937, F-94801 Villejuif, France
[2] Warsaw Canc Ctr, Dept Mol Biol, PL-02781 Warsaw, Poland
关键词:
NUCLEAR EXPORT SIGNALS;
60S RIBOSOMAL-SUBUNITS;
BINDING PROTEIN;
MESSENGER-RNA;
PERINUCLEOLAR COMPARTMENT;
LOCALIZATION;
IDENTIFICATION;
STRESS;
TIAR;
RIBONUCLEOPROTEIN;
D O I:
10.1091/mbc.E08-09-0904
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The translational regulator CPEB1 plays a major role in the control of maternal mRNA in oocytes, as well as of subsynaptic mRNAs in neurons. Although mainly cytoplasmic, we found that CPEB1 protein is continuously shuttling between nucleus and cytoplasm. Its export is controlled by two redundant NES motifs dependent on the nuclear export receptor Crm1. In the nucleus, CPEB1 accumulates in a few foci most often associated with nucleoli. These foci are different from previously identified nuclear bodies. They contain Crm1 and were called Crm1 nucleolar bodies (CNoBs). CNoBs depend on RNA polymerase I activity, indicating a role in ribosome biogenesis. However, although they form in the nucleolus, they never migrate to the nuclear envelope, precluding a role as a mediator for ribosome export. They could rather constitute a platform providing factors for ribosome assembly or export. The behavior of CPEB1 in CNoBs raises the possibility that it is involved in ribosome biogenesis.
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页码:176 / 187
页数:12
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