Ipilimumab-Induced Immunomediated Adverse Events Possible Pitfalls in 18F-FDG PET/CT Interpretation

被引：12

作者：

Gilardi, Laura ^{[1
]}

Colandrea, Marzia ^{[1
]}

Vassallo, Stefano ^{[1
]}

Travaini, Laura Lavinia ^{[1
]}

Paganelli, Giovanni ^{[1
]}

机构：

[1] European Inst Oncol, Div Nucl Med, I-20141 Milan, Italy

来源：

CLINICAL NUCLEAR MEDICINE | 2014年 / 39卷 / 05期

关键词：

PET; CT; F-18-FDG; ipilimumab; immune-related adverse event; METASTATIC MELANOMA; THERAPY;

D O I：

10.1097/RLU.0b013e31828da691

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 42-year-old woman underwent resection of a high-risk melanoma of the right thigh. Adjuvant treatment with ipilimumab was then started within a phase III randomised, double-blind clinical trial. F-18-FDG PET/CT scan showed intense uptake in mediastinal hilar lymph nodes, bilaterally, and in rectus abdominis muscle. Biopsy at the abdominal wall revealed a chronic granulomatous inflammation. After oral steroid treatment, all the areas of abnormal tracer uptake disappeared. Ipilimumab can induce inflammatory immunomediated reactions that should be taken into account to avoid misinterpretation.

引用

页码：472 / 474

页数：3

共 10 条

[1]

Breeman D, 2010, CANC IMMUN, V24, P10

[2] Radiologic Manifestations of Immune-Related Adverse Events in Patients With Metastatic Melanoma Undergoing Anti-CTLA-4 Antibody Therapy [J].

Bronstein, Yulia ;

Ng, Chaan S. ;

Hwu, Patrick ;

Hwu, Wen-Jen .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2011, 197 (06) :W992-W1000

[3] Anti-CTLA-4 Antibody Adjuvant Therapy in Melanoma [J].

Eggermont, Alexander M. M. ;

Testori, Alessandro ;

Maio, Michele ;

Robert, Caroline .

SEMINARS IN ONCOLOGY, 2010, 37 (05) :455-459

[4] Improved Survival with Ipilimumab in Patients with Metastatic Melanoma [J].

Hodi, F. Stephen ;

O'Day, Steven J. ;

McDermott, David F. ;

Weber, Robert W. ;

Sosman, Jeffrey A. ;

Haanen, John B. ;

Gonzalez, Rene ;

Robert, Caroline ;

Schadendorf, Dirk ;

Hassel, Jessica C. ;

Akerley, Wallace ;

van den Eertwegh, Alfons J. M. ;

Lutzky, Jose ;

Lorigan, Paul ;

Vaubel, Julia M. ;

Linette, Gerald P. ;

Hogg, David ;

Ottensmeier, Christian H. ;

Lebbe, Celeste ;

Peschel, Christian ;

Quirt, Ian ;

Clark, Joseph I. ;

Wolchok, Jedd D. ;

Weber, Jeffrey S. ;

Tian, Jason ;

Yellin, Michael J. ;

Nichol, Geoffrey M. ;

Hoos, Axel ;

Urba, Walter J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (08) :711-723

[5] Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review [J].

Juszczak, Agata ;

Gupta, Avinash ;

Karavitaki, Niki ;

Middleton, Mark R. ;

Grossman, Ashley B. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2012, 167 (01) :1-5

[6] Update on Immunologic Therapy With Anti-CTLA-4 Antibodies in Melanoma: Identification of Clinical and Biological Response Patterns, Immune-Related Adverse Events, and Their Management [J].

Kaehler, Katharina C. ;

Piel, Sarah ;

Livingstone, Elisabeth ;

Schilling, Bastian ;

Hauschild, Axel ;

Schadendorf, Dirk .

SEMINARS IN ONCOLOGY, 2010, 37 (05) :485-498

[7] Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy [J].

Min, Le ;

Vaidya, Anand ;

Becker, Carolyn .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2011, 164 (02) :303-307

[8] Reversal of the TCR stop signal by CTLA-4 [J].

Schneider, Helga ;

Downey, Jos ;

Smith, Andrew ;

Zinselmeyer, Bernd H. ;

Rush, Catherine ;

Brewer, James M. ;

Bin Wei ;

Hogg, Nancy ;

Garside, Paul ;

Rudd, Christopher E. .

SCIENCE, 2006, 313 (5795) :1972-1975

[9] Ipilimumab-Induced Sarcoidosis in a Patient With Metastatic Melanoma Undergoing Complete Remission [J].

Vogel, Wouter V. ;

Guislain, Aurelie ;

Kvistborg, Pia ;

Schumacher, Ton N. M. ;

Haanen, John B. A. G. ;

Blank, Christian U. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (02) :E7-E10

[10] Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria [J].

Wolchok, Jedd D. ;

Hoos, Axel ;

O'Day, Steven ;

Weber, Jeffrey S. ;

Hamid, Omid ;

Lebbe, Celeste ;

Maio, Michele ;

Binder, Michael ;

Bohnsack, Oliver ;

Nichol, Geoffrey ;

Humphrey, Rachel ;

Hodi, F. Stephen .

CLINICAL CANCER RESEARCH, 2009, 15 (23) :7412-7420

← 1 →