Antinociceptive and Anti-Inflammatory Activities of the Sesame Oil and Sesamin

被引：94

作者：

Henriques Monteiro, Erika Maria ^{[1
]}

Chibli, Lucas Apolinario ^{[1
]}

Yamamoto, Celia Hitomi ^{[2
]}

Santana Pereira, Monica Cecilia ^{[2
]}

Pinto Vilela, Fernanda Maria ^{[2
]}

Rodarte, Mirian Pereira ^{[2
]}

de Oliveira Pinto, Miriam Aparecida ^{[2
]}

Henriques do Amaral, Maria da Penha ^{[2
]}

Silverio, Marcelo Silva ^{[2
]}

Santos de Matos Araujo, Ana Lucia ^{[2
]}

Andre de Araujo, Ailson da Luz ^{[2
]}

Del-Vechio-Vieira, Glauciemar ^{[2
]}

de Sousa, Orlando Vieira ^{[2
]}

机构：

[1] Univ Fed Juiz de Fora, Fac Pharm, Pharmaceut Sci Postgrad Program, BR-36036900 Juiz De Fora, MG, Brazil

[2] Univ Fed Juiz de Fora, Fac Pharm, Dept Pharmaceut Sci, BR-36036900 Juiz De Fora, MG, Brazil

来源：

NUTRIENTS | 2014年 / 6卷 / 05期

关键词：

sesame oil; sesamin; antinociceptive activity; anti-inflammatory activity; FORMALIN TEST; INDICUM L; ANTIOXIDANT ACTIVITY; OXIDATIVE STABILITY; NITRIC-OXIDE; FIXED OIL; LIGNAN; MECHANISMS; EXTRACTION; ACID;

D O I：

10.3390/nu6051931

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

引用

页码：1931 / 1944

页数：14

共 58 条

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