Exosomes from adipose-derived stem cells and application to skin wound healing

被引：350

作者：

An, Yang ^{[1
]}

Lin, Shuyan ^{[2
]}

Tan, Xiaojie ^{[1
]}

Zhu, Shiou ^{[3
,4
]}

Nie, Fangfei ^{[1
]}

Zhen, Yonghuan ^{[1
]}

Gu, Luosha ^{[1
]}

Zhang, Chunlei ^{[5
]}

Wang, Baicheng ^{[1
]}

Wei, Wei ^{[6
]}

Li, Dong ^{[1
]}

Wu, Junhao ^{[2
]}

机构：

[1] Peking Univ Third Hosp, Dept Plast Surg, 49 North Garden Rd, Beijing 100191, Peoples R China

[2] Sichuan Univ, West China Hosp, Hearing Ctr, Dept Otolaryngol Head & Neck Surg, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China

[4] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China

[5] Peking Univ, Inst Syst Biomed, Beijing, Peoples R China

[6] Peking Univ Third Hosp, Clin Stem Cell Res Ctr, Beijing, Peoples R China

来源：

CELL PROLIFERATION | 2021年 / 54卷 / 03期

关键词：

adipose-derived stem cells; angiogenesis; exosomes; inflammation; skin wound healing;

D O I：

10.1111/cpr.12993

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Skin wound healing is an intractable problem that represents an urgent clinical need. To solve this problem, a large number of studies have focused on the use of exosomes (EXOs) derived from adipose-derived stem cells (ADSCs). This review describes the mechanisms whereby ADSCs-EXOs regulate wound healing and their clinical application. In the wound, ADSCs-EXOs modulate immune responses and inflammation. They also promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling which inhibits scar hyperplasia. Compared with ADSCs therapeutics, ADSCs-EXOs have highly stability and are easily stored. Additionally, they are not rejected by the immune system and have a homing effect and their dosage can be easily controlled. ADSCs-EXOs can improve fat grafting and promote wound healing in patients with diabetes mellitus. They can also act as a carrier and combined scaffold for treatment, leading to scarless cutaneous repair. Overall, ADSCs-EXOs have the potential to be used in the clinic to promote wound healing.

引用

页数：12

共 135 条

[1] Autophagy regulates exosomal release of prions in neuronal cells [J].

Abdulrahman, Basant A. ;

Abdelaziz, Dalia H. ;

Schatzl, Hermann M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (23) :8956-8968

[2] Exosomes from adipose-derived stem cells and application to skin wound healing [J].

An, Yang ;

Lin, Shuyan ;

Tan, Xiaojie ;

Zhu, Shiou ;

Nie, Fangfei ;

Zhen, Yonghuan ;

Gu, Luosha ;

Zhang, Chunlei ;

Wang, Baicheng ;

Wei, Wei ;

Li, Dong ;

Wu, Junhao .

CELL PROLIFERATION, 2021, 54 (03)

[3] The role of matrix vesicles in growth plate development and biomineralization [J].

Anderson, HC ;

Garimella, R ;

Tague, SE .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2005, 10 :822-837

[4] Biomimetic approaches to protein and gene delivery for tissue regeneration [J].

Andreadis, Stelios T. ;

Geer, David J. .

TRENDS IN BIOTECHNOLOGY, 2006, 24 (07) :331-337

[5] Novel Application of Platelet-Rich Fibrin as a Wound Healing Enhancement in Extraction Sockets of Patients Who Smoke [J].

Asmael, Huda Moutaz ;

Jamil, Firas A. ;

Hasan, Ali Mohammed .

JOURNAL OF CRANIOFACIAL SURGERY, 2018, 29 (08) :E794-E797

[6] Human Trophoblast-Derived Exosomal Fibronectin Induces Pro-Inflammatory Il-1β Production by Macrophages [J].

Atay, Safinur ;

Gercel-Taylor, Cicek ;

Taylor, Douglas D. .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2011, 66 (04) :259-269

[7] Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy [J].

Baglio, Serena Rubina ;

Pegtel, D. Michiel ;

Baldini, Nicola .

FRONTIERS IN PHYSIOLOGY, 2012, 3

[8] Syndecan-syntenin-ALIX regulates the biogenesis of exosomes [J].

Baietti, Maria Francesca ;

Zhang, Zhe ;

Mortier, Eva ;

Melchior, Aurelie ;

Degeest, Gisele ;

Geeraerts, Annelies ;

Ivarsson, Ylva ;

Depoortere, Fabienne ;

Coomans, Christien ;

Vermeiren, Elke ;

Zimmermann, Pascale ;

David, Guido .

NATURE CELL BIOLOGY, 2012, 14 (07) :677-685

[9] COLLAGEN POLYMORPHISM IN EXPERIMENTAL GRANULATION TISSUE [J].

BAILEY, AJ ;

SIMS, TJ ;

LELOUS, M ;

BAZIN, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 66 (04) :1160-1165

[10] Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences [J].

Balaj, Leonora ;

Lessard, Ryan ;

Dai, Lixin ;

Cho, Yoon-Jae ;

Pomeroy, Scott L. ;

Breakefield, Xandra O. ;

Skog, Johan .

NATURE COMMUNICATIONS, 2011, 2

← 1 2 3 4 5 6 7 8 9 10 →