Ion-Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules

被引：39

作者：

Kruve, Anneli ^{[1
]}

Caprice, Kenji ^{[2
]}

Lavendomme, Roy ^{[3
]}

Wollschlaeger, Jan M. ^{[1
]}

Schoder, Stefan ^{[1
]}

Schroeder, Hendrik V. ^{[1
]}

Nitschke, Jonathan R. ^{[3
]}

Cougnon, Fabien B. L. ^{[2
]}

Schalley, Christoph A. ^{[1
,4
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany

[2] Univ Geneva, Dept Organ Chem, 30 Quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland

[3] Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England

[4] Northwestern Polytech Univ, Sch Life Sci, 127 Youyi Xilu, Xian 710072, Shaanxi, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 33期

基金：

瑞士国家科学基金会; 英国工程与自然科学研究理事会; 欧洲研究理事会;

关键词：

intertwined molecules; ion-mobility spectrometry; Solomon link; tandem mass spectrometry; trefoil knot; CATENANES; MACROCYCLES; ROTAXANES; CHEMISTRY;

D O I：

10.1002/anie.201904541

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rapid screening method based on traveling-wave ion-mobility spectrometry (TWIMS) combined with tandem mass spectrometry provides insight into the topology of interlocked and knotted molecules, even when they exist in complex mixtures, such as interconverting dynamic combinatorial libraries. A TWIMS characterization of structure-indicative fragments generated by collision-induced dissociation (CID) together with a floppiness parameter defined based on parent- and fragment-ion arrival times provide a straightforward topology identification. To demonstrate its broad applicability, this approach is applied here to six Hopf and two Solomon links, a trefoil knot, and a [3]catenate.

引用

页码：11324 / 11328

页数：5

共 50 条

[41] THE LASER DESORPTION OF ORGANIC-MOLECULES IN ION MOBILITY SPECTROMETRY
PHILLIPS, J
GORMALLY, J
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1992, 112 (2-3): : 205 - 214
[42] Metabolic profiling by ion mobility mass spectrometry (IMMS)
Dwivedi, Prabha
Wu, Peiying
Klopsch, Steve J.
Puzon, Geoffrey J.
Xun, Luying
Hill, Herbert H., Jr.
METABOLOMICS, 2008, 4 (01) : 63 - 80
[43] Detection of tetrahydrocannabinol residues on hands by ion-mobility spectrometry (IMS). Correlation of IMS data with saliva analysis
Saskia Sonnberg
Sergio Armenta
Salvador Garrigues
Miguel de la Guardia
Analytical and Bioanalytical Chemistry, 2015, 407 : 5999 - 6008
[44] Metabolic profiling by ion mobility mass spectrometry (IMMS)
Prabha Dwivedi
Peiying Wu
Steve J. Klopsch
Geoffrey J. Puzon
Luying Xun
Herbert H. Hill
Metabolomics, 2008, 4 : 63 - 80
[45] Hybrid ion mobility and mass spectrometry as a separation tool
Ewing, Michael A.
Glover, Matthew S.
Clemmer, David E.
JOURNAL OF CHROMATOGRAPHY A, 2016, 1439 : 3 - 25
[46] Detection of tetrahydrocannabinol residues on hands by ion-mobility spectrometry (IMS). Correlation of IMS data with saliva analysis
Sonnberg, Saskia
Armenta, Sergio
Garrigues, Salvador
de la Guardia, Miguel
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2015, 407 (20) : 5999 - 6008
[47] Letter: A simple ion source set-up for desorption/ionization on silicon with ion mobility spectrometry and ion mobility spectrometry-mass spectrometry
Adamov, Alexey
Sysoev, Alexey A.
Grigoras, Kestutis
Laakia, Jaakko
Kotiaho, Tapio
EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2011, 17 (06) : 593 - 597
[48] Pyrolysis Gas-Chromatography Ion-Mobility Spectrometry data analysis for chemical detection in water monitoring
Ren, H
Jensen, J
Loerop, W
CHEMICAL AND BIOLOGICAL POINT SENSORS FOR HOMELAND DEFENSE, 2004, 5269 : 126 - 131
[49] An electrostatic focusing ion guide for ion mobility-mass spectrometry
Gillig, KJ
Ruotolo, BT
Stone, EG
Russell, DH
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2004, 239 (01) : 43 - 49
[50] Ion mobility spectrometer-field asymmetric ion mobility spectrometer-mass spectrometry
Pollard, Matthew J.
Hilton, Christopher K.
Li, Hongli
Kaplan, Kimberly
Yost, Richard A.
Hill, Herbert H., Jr.
INTERNATIONAL JOURNAL FOR ION MOBILITY SPECTROMETRY, 2011, 14 (01) : 15 - 22

← 1 2 3 4 5 →