Ion-Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules

被引：39

作者：

Kruve, Anneli ^{[1
]}

Caprice, Kenji ^{[2
]}

Lavendomme, Roy ^{[3
]}

Wollschlaeger, Jan M. ^{[1
]}

Schoder, Stefan ^{[1
]}

Schroeder, Hendrik V. ^{[1
]}

Nitschke, Jonathan R. ^{[3
]}

Cougnon, Fabien B. L. ^{[2
]}

Schalley, Christoph A. ^{[1
,4
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany

[2] Univ Geneva, Dept Organ Chem, 30 Quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland

[3] Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England

[4] Northwestern Polytech Univ, Sch Life Sci, 127 Youyi Xilu, Xian 710072, Shaanxi, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 33期

基金：

英国工程与自然科学研究理事会; 瑞士国家科学基金会; 欧洲研究理事会;

关键词：

intertwined molecules; ion-mobility spectrometry; Solomon link; tandem mass spectrometry; trefoil knot; CATENANES; MACROCYCLES; ROTAXANES; CHEMISTRY;

D O I：

10.1002/anie.201904541

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rapid screening method based on traveling-wave ion-mobility spectrometry (TWIMS) combined with tandem mass spectrometry provides insight into the topology of interlocked and knotted molecules, even when they exist in complex mixtures, such as interconverting dynamic combinatorial libraries. A TWIMS characterization of structure-indicative fragments generated by collision-induced dissociation (CID) together with a floppiness parameter defined based on parent- and fragment-ion arrival times provide a straightforward topology identification. To demonstrate its broad applicability, this approach is applied here to six Hopf and two Solomon links, a trefoil knot, and a [3]catenate.

引用

页码：11324 / 11328

页数：5

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