Copper Transport in Mammalian Cells: Special Care for a Metal with Special Needs

被引：124
作者：
Kaplan, Jack H. [1 ]
Lutsenko, Svetlana [2 ]
机构：
[1] Univ Illinois, Dept Biochem & Mol Genet, Chicago, IL 60607 USA
[2] Johns Hopkins Univ, Dept Physiol, Baltimore, MD 21205 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2009年 / 284卷 / 38期
基金：
美国国家卫生研究院;
关键词：
WILSONS-DISEASE PROTEIN; P-TYPE ATPASES; BIOCHEMICAL-CHARACTERIZATION; THERMOTOGA-MARITIMA; EPITHELIAL-CELLS; PLASMA-MEMBRANE; HUMAN CTR1; HCTR1; MECHANISM; HOMEOSTASIS;
D O I：
10.1074/jbc.R109.031286
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Copper plays an essential role in human physiology. It is required for respiration, radical defense, neuronal myelination, angiogenesis, and many other processes. Copper has distinct physicochemical properties that pose uncommon challenges for its transport across biological membranes. Only small amounts of copper are present in biological fluids, and essentially none of it exists in a free ion form. These properties and the low redox potential of copper dictate special structural and mechanistic features in copper transporters. This minireview discusses molecular mechanisms through which copper enters and exits human cells.
引用
收藏
页码：25461 / 25465
页数：5
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