Akineto-rigid vs. tremor syndromes in Parkinsonism

被引：128

作者：

Zaidel, Adam ^{[1
,2
]}

Arkadir, David ^{[3
]}

Israel, Zvi ^{[4
]}

Bergman, Hagai ^{[1
,2
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Physiol, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Interdisciplinary Ctr Neural Computat, IL-91120 Jerusalem, Israel

[3] Hadassah Hebrew Univ, Med Ctr, Dept Neurol, Jerusalem, Israel

[4] Hadassah Hebrew Univ, Med Ctr, Dept Neurosurg, Jerusalem, Israel

来源：

CURRENT OPINION IN NEUROLOGY | 2009年 / 22卷 / 04期

关键词：

basal ganglia; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; oscillations; Parkinson's disease; synchronization; DOPAMINE REPLACEMENT THERAPY; PRIMATE SUBTHALAMIC NUCLEUS; GLOBUS-PALLIDUS NEURONS; BASAL GANGLIA; MPTP MODEL; PATHOLOGICAL SYNCHRONIZATION; BETA-OSCILLATIONS; DISEASE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ORGANIZATION;

D O I：

10.1097/WCO.0b013e32832d9d67

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose of review Akinesia, rigidity and low-frequency rest tremor are the three cardinal motor signs of Parkinson's disease and some Parkinson's disease animal models. However, cumulative evidence supports the view that akinesia/rigidity vs. tremor reflect different pathrophysiological phenomena in the basal ganglia. Here, we review the recent physiological literature correlating abnormal neural activity in the basal ganglia with Parkinson's disease clinical symptoms. Recent findings The subthalamic nucleus of Parkinson's disease patients is characterized by oscillatory activity in the beta-frequency (similar to 15 Hz) range. However, Parkinson's disease tremor is not strictly correlated with the abnormal synchronous oscillations of the basal ganglia. On the other hand, akinesia and rigidity are better correlated with the basal ganglia beta oscillations. Summary The abnormal basal ganglia output leads to akinesia and rigidity. Parkinson's disease tremor most likely evolves as a downstream compensatory mechanism.

引用

页码：387 / 393

页数：7

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