Stroke is one of the leading causes of death and long-term disability, with limited treatment options available. Inflammation contributes to damage tissue in the central nervous system across a broad range of neuropathologies, including Alzheimer's disease, pain, Schizophrenia, and stroke. While the immune system plays an important role in contributing to brain damage produced by ischemia, the damaged brain, in turn, can exert a powerful immune-suppressive effect that promotes infections and threatens the survival of stroke patients. Recently the cholinergic anti-inflammatory pathway, in particular its modulation using alpha 7-nicotinic acetylcholine receptor (alpha 7-nAChR) ligands, has shown potential as a strategy to dampen the inflammatory response and facilitate functional recovery in stroke patients. Here we discuss the current literature on stroke-induced inflammation and the effects of alpha 7-nAChR modulators on innate immune cells.
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Univ Washington, Dept Microbiol, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
Bergsbaken, Tessa
Fink, Susan L.
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Univ Washington, Dept Mol & Cellular Biol, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
Fink, Susan L.
Cookson, Brad T.
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Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
Univ Washington, Dept Lab Med, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
机构:
Univ Washington, Dept Microbiol, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
Bergsbaken, Tessa
Fink, Susan L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Mol & Cellular Biol, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
Fink, Susan L.
Cookson, Brad T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
Univ Washington, Dept Lab Med, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA