Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective

被引:45
作者
Neumann, Silke [1 ,2 ,3 ]
Shields, Nicholas J. [1 ]
Balle, Thomas [4 ]
Chebib, Mary [4 ]
Clarkson, Andrew N. [2 ,3 ,4 ]
机构
[1] Univ Otago, Dept Pathol, Dunedin 9054, New Zealand
[2] Univ Otago, Dept Anat, Brain Hlth Res Ctr, Dunedin 9054, New Zealand
[3] Univ Otago, Brain Res New Zealand, Dunedin 9054, New Zealand
[4] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia
来源
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 12期
基金
英国医学研究理事会;
关键词
stroke; inflammation; nicotinic; nicotinic acetylcholine receptor agonist; immune response; myeloid cells; NEURONAL NICOTINIC RECEPTORS; FOCAL CEREBRAL-ISCHEMIA; VAGUS NERVE-STIMULATION; GROUP BOX-1 PROTEIN; BRAIN-INJURY; SUPPRESSOR-CELLS; ACETYLCHOLINESTERASE INHIBITORS; MICROGLIAL ACTIVATION; IL-1-BETA PRODUCTION; MYELOID CELLS;
D O I
10.3390/ijms161226141
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Stroke is one of the leading causes of death and long-term disability, with limited treatment options available. Inflammation contributes to damage tissue in the central nervous system across a broad range of neuropathologies, including Alzheimer's disease, pain, Schizophrenia, and stroke. While the immune system plays an important role in contributing to brain damage produced by ischemia, the damaged brain, in turn, can exert a powerful immune-suppressive effect that promotes infections and threatens the survival of stroke patients. Recently the cholinergic anti-inflammatory pathway, in particular its modulation using alpha 7-nicotinic acetylcholine receptor (alpha 7-nAChR) ligands, has shown potential as a strategy to dampen the inflammatory response and facilitate functional recovery in stroke patients. Here we discuss the current literature on stroke-induced inflammation and the effects of alpha 7-nAChR modulators on innate immune cells.
引用
收藏
页码:29029 / 29046
页数:18
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