Colchicine for the treatment of cardiovascular diseases: old drug, new targets

被引：26

作者：

Andreis, Alessandro ^{[1
]}

Imazio, Massimo ^{[1
]}

De Ferrari, Gaetano Maria ^{[1
]}

机构：

[1] AOU Citta Salute & Sci Torino, Univ Cardiol, Corso Bramante 88, I-10126 Turin, Italy

来源：

JOURNAL OF CARDIOVASCULAR MEDICINE | 2021年 / 22卷 / 01期

关键词：

colchicine; coronary artery disease; inflammation; pericardial diseases; POSTOPERATIVE ATRIAL-FIBRILLATION; ACUTE MYOCARDIAL-INFARCTION; PULMONARY VEIN ISOLATION; ACUTE CORONARY SYNDROME; C-REACTIVE PROTEIN; RECURRENT PERICARDITIS; DOUBLE-BLIND; POSTPERICARDIOTOMY-SYNDROME; ANTIINFLAMMATORY TREATMENT; RANDOMIZED-TRIAL;

D O I：

10.2459/JCM.0000000000001079

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Well known in past centuries as a herbal remedy for osteoarticular pain and commonly used in the treatment of gout and familial Mediterranean fever, colchicine has an emerging role in the setting of cardiovascular diseases. Its unique properties not only target the key mechanisms of recurrent inflammation underlying pericardial syndromes but also inflammation within atherosclerotic plaques, atrial fibrillation recurrence and adverse ventricular remodelling leading to heart failure. The effect of colchicine in the treatment of cardiovascular diseases along with essential pharmacology will be discussed, reviewing the most important and recent clinical studies. Colchicine is a valuable, well tolerated and inexpensive drug in the setting of cardiovascular diseases.

引用

页码：1 / 8

页数：8

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